Electroacupuncture promotes neural stem cell proliferation and neurogenesis in the dentate gyrus of rats following stroke via upregulation of Notch1 expression

Molecular Medicine Reports
Junhong ZhaoTiebin Yan

Abstract

Neural stem cells (NSCs) are important in rehabilitation following stroke. Electroacupuncture (EA) treatment has been observed to promote the recovery of neurological functions subsequent to stroke, however, the effects of EA on the proliferation and differentiation of NSCs and its potential mechanisms remain to be elucidated. In the present study, rats, in which a stroke was induced through middle cerebral artery occlusion (MCAO), were treated with EA or control manipulation for 21 days. The modified Neurological Severity score and Morris water maze tests were used to assess the neurological functions of the rats. Bromodeoxyuridine (BrdU)/glial fibrillary acidic protein (GFAP) or BrdU/neuronal marker (NeuN) double immunofluorescence staining were used to examine the proliferation and differentiation of the NSCs. Reverse transcription quantitative polymerase chain reaction (RT‑qPCR) and western blot analyses were performed to detect the expression levels of Notch1 and Hes1 in the dentate gyrus (DG) of the hippocampus of rats following MCAO. The results demonstrated that EA treatment significantly improved the neurological functional recovery of rats following stroke. A significant increase was observed in the number of BrdU+/GA...Continue Reading

References

Sep 1, 1996·Trends in Neurosciences·S WeissD van der Kooy
Apr 4, 1997·Science·R McKay
Jul 1, 1998·Biological Psychiatry·G A UlettJ S Han
Dec 16, 1998·Southern Medical Journal·S Ceniceros, G R Brown
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·K JinD A Greenberg
Jul 21, 2001·CNS Drugs·D S Liebeskind, S E Kasner
Jul 27, 2001·Journal of Public Health Medicine·S KavanaghA Patel
Mar 14, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ken-ichiro TakasawaMasayasu Matsumoto
May 29, 2002·Brain Research Bulletin·James Santiago Grisolía
Aug 6, 2002·Nature Medicine·Andreas ArvidssonOlle Lindvall
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·D Chichung LieFred H Gage
Sep 12, 2006·Neuroscience·P MohapelH Frielingsdorf
Feb 26, 2008·Cell·Chunmei ZhaoFred H Gage
Apr 2, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yi-jing GuoYi Sun
Jun 27, 2009·Stroke; a Journal of Cerebral Circulation·Zhang JunhuaRoberto Raschetti
Jun 26, 2012·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Min-Wook KimManho Kim
Aug 11, 2012·Current Topics in Behavioral Neurosciences·Yan GuShaoyu Ge
Dec 25, 2012·Stem Cells and Development·David PiccinCindi M Morshead
Nov 5, 2013·Neuron·Fred H Gage, Sally Temple

❮ Previous
Next ❯

Citations

Nov 8, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Ling-Yong XiaoCun-Zhi Liu
Aug 2, 2017·Stem Cells International·Weilin XuAnwen Shao
May 6, 2016·Neuroscience Bulletin·Fengyun ZhangDongya Zhu
May 7, 2020·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Danmei ChenWei Fan
Nov 26, 2020·Journal of Neuropathology and Experimental Neurology·Miao ChenHairong Wang
Nov 25, 2020·Neural Regeneration Research·Bing-Qian CaoPeng-Hui Lai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.