Electroacupuncture protects against articular cartilage erosion by inhibiting mitogen-activated protein kinases in a rat model of osteoarthritis

Acupuncture in Medicine : Journal of the British Medical Acupuncture Society
Ying LiaoJun Zhou

Abstract

The therapeutic effects of electroacupuncture (EA) on osteoarthritis (OA) are well documented; however, the precise mechanisms of action have not yet been fully elucidated. The present study aimed to investigate the effect of EA on cartilage in an experimental animal model of OA induced by anterior cruciate ligament transection (ACLT) and to examine for concomitant changes in the expression of mitogen-activated protein kinases (MAPKs) in the articular cartilage. Thirty-three-month-old male Sprague Dawley rats were randomly divided into the following three groups (n=10 each): sham operated group (Control group), ACLT without treatment (ACLT group), and ACLT with EA treatment (ACLT+EA group). One week after ACLT, rats in the ACLT+EA group received 12 weeks of EA treatment. Histological analysis and quantitative real-time PCR were used to investigate the effects of EA on cartilage morphology (quantified using modified Mankin scores) and expression of MAPKs (p38, c-Jun N-terminal kinase (c-Jun), and extracellular signal-regulated kinase (ERK)1), respectively. ACLT produced coarse cartilage surfaces, fibrous degeneration, and fissuring, all of which were suppressed by EA treatment. Although Mankin scores in the ACLT+EA group were si...Continue Reading

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Citations

Nov 20, 2016·Physical Therapy in Sport : Official Journal of the Association of Chartered Physiotherapists in Sports Medicine·Jun ZhouNeng Li
Apr 8, 2018·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Xuefeng ZhengYanping Lin
Mar 5, 2018·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Danchun LanWei Yi
Feb 14, 2018·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Dawei TianMin Li
Mar 10, 2018·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Lu YangDavid William Sibbritt
Jul 11, 2018·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Ding LuoWenbin Fu
Nov 3, 2017·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Jun ZhouYahua Zeng
Nov 10, 2017·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Qinhong ZhangYing Lu
Apr 16, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Hsiang-Chun LaiChing-Liang Hsieh
Jan 17, 2020·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Hsin-Cheng HsuYi-Wen Lin
Feb 11, 2021·Animals : an Open Access Journal From MDPI·Melinda R StoryC Wayne McIlwraith
Jun 10, 2021·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Alexa P SpittlerKelly S Santangelo

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