Electroacupuncture reduces the expression of proinflammatory cytokines in inflamed skin tissues through activation of cannabinoid CB2 receptors

European Journal of Pain : EJP
T-F SuMan Li

Abstract

Endogenous cannabinoids and peripheral cannabinoid CB2 receptors (CB2Rs) are involved in the antinociceptive effect of electroacupuncture (EA) on inflammatory pain. However, it is not clear how CB2R activation contributes to the antinociceptive effect of EA. The major proinflammatory cytokines, such as tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and IL-6, are involved in inflammatory pain. Here we determined the effects of CB2R activation and EA on the expression level of IL-1β, IL-6 and TNF-α in inflamed skin tissues. Inflammatory pain was induced by injection of complete Freund's adjuvant into the left hindpaw of rats. Thermal hyperalgesia was tested with a radiant heat stimulus, and mechanical allodynia was quantified using von Frey filaments. The mRNA and protein levels of IL-1β, IL-6 and TNF-α in inflamed skin tissues were measured using real-time polymerase chain reaction and Western blot, respectively. Local injection of the selective CB2R agonist AM1241 or EA applied to GB30 and GB34 significantly reduced thermal hyperalgesia and mechanical allodynia induced by tissue inflammation. The specific CB2R antagonist AM630 significantly attenuated the antinociceptive effect of EA. Furthermore, EA or AM1241 treatme...Continue Reading

References

Nov 1, 1992·British Journal of Pharmacology·F Q CunhaS H Ferreira
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·L FacciA Leon
Nov 1, 1994·Journal of Leukocyte Biology·K Kuno, K Matsushima
Jan 1, 1993·Advances in Immunology·S AkiraT Kishimoto
Aug 26, 1998·The Biochemical Journal·P C HeinrichL Graeve
Nov 11, 1998·JAMA : the Journal of the American Medical Association
Nov 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S SuzukiY Fukuuchi
Aug 11, 2001·Journal of Neuroimmunology·J C CoprayH W Boddeke
Aug 22, 2001·Pain·Philip T MalanAlexandros Makriyannis
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Otilia ObrejaMichaela Kress
Nov 12, 2003·The Journal of Pharmacology and Experimental Therapeutics·Andrea G HohmannAlexandros Makriyannis
Feb 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mohab M IbrahimT Philip Malan
Nov 4, 2005·The American Journal of Chinese Medicine·Kaung-Ti Yung
Dec 17, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Neera Tewari-SinghRajesh Agarwal

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Citations

Dec 15, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jill BouchardPaul J Muchowski
Aug 21, 2013·Clinical & Developmental Immunology·Gisa EllrichmannRalf A Linker
Sep 3, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ji-Yeun ParkWoong Mo Yang
Sep 27, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Liciane F MedeirosIraci L S Torres
Jun 6, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Tae-Woong MoonEdzard Ernst
Mar 6, 2015·Journal of Periodontology·Mario R P LisboaFlávia A C Furlaneto
Jun 9, 2016·Journal of Neuroinflammation·Ya-Qun ZhouYu-Ke Tian
Aug 25, 2016·Journal of Acupuncture and Meridian Studies·Marcelo Lourenço SilvaWiliam Alves Prado
Nov 2, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Junying WangGerhard Litscher
Oct 13, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Krishnan V ChakravarthyThomas M Kinfe
Mar 1, 2018·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Xiaoyan JieJian-Hua Wang
Feb 2, 2019·Chinese Journal of Integrative Medicine·Fu-Ming YangYang-Yang Liu
Dec 11, 2013·Anesthesiology·Ruixin ZhangBrian M Berman
May 21, 2020·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Lourdes Arriaga-PizanoRafael Torres-Rosas
Sep 4, 2020·Experimental Biology and Medicine·Bocun LiCai Guowei
May 26, 2018·Current Opinion in Anaesthesiology·Bihua BieMohamed Naguib
Mar 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kinga Fanni TóthAttila Oláh
Sep 13, 2019·International Journal of Molecular Sciences·Chia-Ming YenYi-Wen Lin
Sep 12, 2017·Journal of Acupuncture and Meridian Studies·Cuicui ChenYan Wang
Oct 19, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jia SunDa-Wei Ye
Oct 17, 2020·The Spine Journal : Official Journal of the North American Spine Society·James DunningCésar Fernández-de-Las-Peñas
Jan 22, 2021·Pflügers Archiv : European journal of physiology·Maísa Maria Spagnol TrentoDaniel Fernandes Martins
Mar 9, 2021·Frontiers in Neuroscience·Iona J MacDonald, Yi-Hung Chen
Aug 24, 2021·Expert Opinion on Therapeutic Targets·David CabañeroRafael Maldonado

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