Electroacupuncture regulate hypothalamic-pituitary-adrenal axis and enhance hippocampal serotonin system in a rat model of depression

Neuroscience Letters
Jing-Jing LeJingcheng Dong

Abstract

Hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the pathogenesis of depression. Dysfunction of the hippocampal serotonin (5-hydroxytryptamine, 5-HT) system has been shown to be a key factor in depression. There is growing evidence that electro-acupuncture (EA) has antidepressant-like effect. However, the effect of EA on HPA axis and hippocampal serotonin system remains unknown. In our study, we investigated the antidepressant-like effect and mechanism of EA for depression rat models. Depression in rats was induced by chronic unpredictable mild stress (CUMS). EA treatment was administered once daily to CUMS rats for 14 days. The acupoints (ST36, bilateral and CV4) were selected. Untreated CUMS rats and normal rats were used as controls. Behavioral tests including forced swim test and open-field test were performed to evaluate the antidepressant effects of EA treatment. Hypothalamic corticotropin-releasing hormone (CRH) mRNA, plasma adrenocorticotropic hormone (ACTH) and corticosterone (CORT) were estimated as indices of HPA axis activity. Enzyme linked immunosorbent assay (ELISA) was performed to determine the concentrations of 5-HT in the hippocampus. Real-time PCR(RT-PCR)and Western blot were respectively used...Continue Reading

References

Jul 1, 1998·Biological Psychiatry·G A UlettJ S Han
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Daniel HoyerGraeme R Martin
Feb 12, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mounira BanasrAnnie Daszuta
Apr 10, 2004·BMJ : British Medical Journal·Jon N JureidiniAnne L Tonkin
Oct 9, 2007·Nuclear Medicine and Biology·Wayne C DrevetsChester Mathis
Apr 29, 2008·Neuroscience and Biobehavioral Reviews·Andrew Holmes
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Kaoru Okada, Kenji Kawakita
Apr 30, 2009·Nature Reviews. Neuroscience·Sonia J LupienChristine Heim
Apr 20, 2010·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Shao-Jun WangLian-Hong Tan
May 26, 2010·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Lisa M ThorntonWendy P Blakely
May 8, 2013·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Hua SunWei He
Jun 6, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jian YangXin Ma
Aug 13, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·H MacphersonS Richmond
Dec 5, 2013·Neuroscience and Biobehavioral Reviews·Ian MaharJosé N Nobrega
Apr 25, 2014·Medical Acupuncture·David P Sniezek, Imran J Siddiqui
Dec 20, 2014·Behavioural Brain Research·Matthew BoykoAlexander Zlotnik
Feb 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Benjamin D SachsMarc G Caron
Apr 19, 2015·BMC Complementary and Alternative Medicine·Shao-jun WangSi-ting Li

❮ Previous
Next ❯

Citations

Dec 26, 2018·Immunology and Cell Biology·Sayan GhoshSreya Chattopadhyay
Dec 19, 2020·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Kun ZhangWeidong Shen
Aug 2, 2019·Journal of Chiropractic Medicine·Brett R Martin
Mar 4, 2020·Brain, Behavior, and Immunity·Andrew J Perrin, Carmine M Pariante
Sep 24, 2019·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Xinjing YangYa Tu
Dec 11, 2021·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Xiao-Ning ZhangBing Zhu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.