Abstract
Plasma concentration of B-type natriuretic peptide (BNP) has been suggested as a powerful screening tool for left ventricular systolic dysfunction. However, there are reports indicating that the 12-lead electrocardiogram (ECG) could be just as powerful. We aimed to evaluate the 12-lead ECG and BNP as screening tools for left ventricular systolic dysfunction in an elderly, unselected population. In a randomly selected population-based sample of 75-year-old men and women (n = 407), diagnostic characteristics were evaluated for the ECG and plasma concentration of BNP to detect left ventricular systolic dysfunction. Sensitivity, specificity, and negative and positive predictive values for the ECG to detect left ventricular systolic dysfunction were 96%, 79%, 100%, and 26%, respectively. The corresponding values for the BNP (cut-off value 28 pg/mL) were 93%, 55%, 99%, and 13%. In participants without major abnormalities in the ECG, left ventricular systolic dysfunction was found in <1% (1/302), irrespective of BNP concentrations. In participants with abnormal ECGs, systolic dysfunction was more prevalent in persons with abnormal BNP concentrations than in those with normal concentrations (35% vs 3%, difference 32%, 95%CI for the dif...Continue Reading
References
Sep 1, 1979·Circulation·J J HegerH Feigenbaum
Sep 13, 1992·The New England Journal of Medicine·M A PfefferG C Flaker
Sep 3, 1992·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJ N Cohn
Jan 1, 1992·Cardiology·J BerningP E Andersen
Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Jan 1, 1968·Monograph Series·G A Rose, H Blackburn
Oct 1, 1993·Journal of the American College of Cardiology·K K HoD Levy
Jan 27, 1996·BMJ : British Medical Journal·A P DavieJ J McMurray
Sep 1, 1996·Heart·T OmlandH Vik-Mo
May 1, 1997·The American Journal of Cardiology·T F ChristianR J Gibbons
Oct 6, 1997·Lancet·T A McDonaghH J Dargie
Nov 21, 1997·Journal of Internal Medicine·T WallénK Nakao
Jan 20, 1998·Lancet·T A McDonaghH J Dargie
Jul 4, 1998·European Heart Journal·J V McMurrayC Morrison
Apr 23, 1999·European Heart Journal·M R CowieG C Sutton
Mar 31, 2000·BMJ : British Medical Journal·H SmithD Mant
Apr 5, 2001·European Heart Journal·P HedbergI Ringqvist
Sep 22, 2001·The American Journal of Medicine·P KrishnaswamyA S Maisel
Citations
May 1, 2008·Environmental Health and Preventive Medicine·Shinji FukazawaTooru Tsunoda
Sep 1, 2009·Age and Ageing·Bert VaesJan Degryse
Jun 23, 2010·BMC Cardiovascular Disorders·Todd T SchlegelOlle Pahlm
Oct 2, 2013·International Journal of Cardiology·Michele McGradyHenry Krum
Jun 12, 2009·Critical Reviews in Clinical Laboratory Sciences·Aldo ClericoMichele Emdin
Mar 3, 2011·Mayo Clinic Proceedings·Lisa C Costello-BoerrigterJohn C Burnett
Jul 28, 2009·Heart Failure Clinics·Guido BoerrigterJohn C Burnett
Oct 30, 2007·International Journal of Cardiology·Frans H Rutten, Arno W Hoes
Oct 9, 2007·Clinical Biochemistry·Stephen A HillParminder S Raina
Oct 4, 2008·Congestive Heart Failure·Theresa A McDonaghAlan S Maisel
Feb 23, 2008·Internal Medicine Journal·B EwaldJ Attia
Apr 25, 2006·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Shlomo Stern
Nov 17, 2007·European Journal of Heart Failure·Kevin M GoodeJohn G F Cleland
Mar 15, 2012·European Journal of Heart Failure·Gillian MurtaghKenneth M McDonald
Jul 11, 2006·American Heart Journal·W H Wilson Tang
Jan 1, 2013·Journal of Personalized Medicine·Patrick A GladdingTodd T Schlegel
May 17, 2006·Circulation·Shlomo Stern
Apr 22, 2006·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Göran NilssonJ Ohrvik
May 13, 2020·Nature Medicine·Sushravya RaghunathBrandon K Fornwalt