Electrocardiogram in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy patients without any clinical evidence of coronary artery disease: a case-control study

Stroke; a Journal of Cerebral Circulation
Rodica CumurciucK Vahedi

Abstract

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited systemic arteriopathy caused by highly stereotyped mutations in NOTCH3. The clinical expression of CADASIL is confined to the central nervous system with characteristic recurrent subcortical infarcts and vascular dementia. However, cases have been reported with associated circulatory small vessel abnormalities in the retina or the myocardium and with myocardial infarction. Classical cardiovascular risk factors may influence such circulatory abnormalities. Thus, we conducted a case control study to determine the frequency of electrical abnormalities on a 12-lead resting ECG in CADASIL patients without classical atherosclerotic risk factors. Twenty-three CADASIL patients (mean age+/-SD; 55.1+/-11 years) free of any classical cardiovascular risk factors except for hypercholesterolemia were recruited from 1 neurology department and compared with 23 sex- and age-matched healthy controls (mean age+/-SD; 54.7+/-9.5 years). A resting supine 12-lead ECG was recorded at inclusion and analyzed later by 2 reviewers. Signs of myocardial infarction or ischemia, conduction, and rhythm disturbances were looked for. We found no E...Continue Reading

References

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Citations

Sep 20, 2007·Cerebrovascular Diseases·Josef Finsterer
Jun 23, 2009·Lancet Neurology·Hugues ChabriatMarie-Germaine Bousser
Sep 4, 2012·The Journal of Headache and Pain·Cherubino Di LorenzoFilippo M Santorelli
Oct 18, 2014·Brain Pathology·Saara TikkaHannu Kalimo
Jul 5, 2016·Neurologia i neurochirurgia polska·Julia BuczekAnna Członkowska
Nov 4, 2010·Journal of Geriatric Psychiatry and Neurology·D Hervé, H Chabriat
May 14, 2010·Arquivos de neuro-psiquiatria·Charles André

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