Pediatric sudden cardiac death (SCD) occurs in an estimated 0.8 to 6.2 per 100 000 children annually. Screening for cardiac disorders causing SCD in asymptomatic children has public appeal because of its apparent potential to avert tragedy; however, performance of the electrocardiogram (ECG) as a screening tool is unknown. We estimated (1) phenotypic (ECG- or echocardiogram [ECHO]-based) prevalence of selected pediatric disorders associated with SCD, and (2) sensitivity, specificity, and predictive value of ECG, alone or with ECHO. We systematically reviewed literature on hypertrophic cardiomyopathy (HCM), long QT syndrome (LQTS), and Wolff-Parkinson-White syndrome, the 3 most common disorders associated with SCD and detectable by ECG. We identified and screened 6954 abstracts, yielding 396 articles, and extracted data from 30. Summary phenotypic prevalences per 100 000 asymptomatic children were 45 (95% confidence interval [CI]: 10-79) for HCM, 7 (95% CI: 0-14) for LQTS, and 136 (95% CI: 55-218) for Wolff-Parkinson-White. The areas under the receiver operating characteristic curves for ECG were 0.91 for detecting HCM and 0.92 for LQTS. The negative predictive value of detecting either HCM or LQTS by using ECG was high; however...Continue Reading
Equivocal and borderline myocardial hypertrophy in relatives of patients with hypertrophic cardiomyopathy: possible implications in genetics of the disease
The spectrum of echocardiographic and electrocardiographic abnormalities in nonaffected relatives of patients with hypertrophic cardiomyopathy: a transverse and longitudinal study
Diagnostic value of electrocardiography and echocardiography for familial hypertrophic cardiomyopathy in a genotyped adult population
Epidemiology of idiopathic cardiomyopathies in children and adolescents. A nationwide study in Finland
Diagnostic performance of QT interval variables from 24-h electrocardiography in the long QT syndrome
Evaluation of QT interval duration and dispersion and proposed clinical criteria in diagnosis of long QT syndrome in patients with a genetically uniform type of LQT1
Diagnostic value of electrocardiography and echocardiography for familial hypertrophic cardiomyopathy in genotyped children
Electrocardiographic prediction of abnormal genotype in congenital long QT syndrome: experience in 101 related family members
Clinical value of electrocardiographic parameters in genotyped individuals with familial long QT syndrome
Assessment of diastolic function with Doppler tissue imaging to predict genotype in preclinical hypertrophic cardiomyopathy
Accuracy of European diagnostic criteria for familial hypertrophic cardiomyopathy in a genotyped population
Prevalence of idiopathic hypertrophic cardiomyopathy in China: a population-based echocardiographic analysis of 8080 adults
Diagnostic value of abnormal Q waves for identification of preclinical carriers of hypertrophic cardiomyopathy based on a molecular genetic diagnosis
Recommendations and considerations related to preparticipation screening for cardiovascular abnormalities in competitive athletes: 2007 update: a scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology Foundation
Cardiovascular monitoring of children and adolescents with heart disease receiving medications for attention deficit/hyperactivity disorder [corrected]: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young Congenital Cardiac Defects Committee and the Council on Cardiovascular Nursing
The response of the QT interval to the brief tachycardia provoked by standing: a bedside test for diagnosing long QT syndrome.
Cost-effectiveness of preparticipation screening for prevention of sudden cardiac death in young athletes.
Modeled economic evaluation of alternative strategies to reduce sudden cardiac death among children treated for attention deficit/hyperactivity disorder
Detection of hypertrophic cardiomyopathy is improved when using advanced rather than strictly conventional 12-lead electrocardiogram
Screening for sudden cardiac death in the young: report from a national heart, lung, and blood institute working group
Costs and benefits of targeted screening for causes of sudden cardiac death in children and adolescents.
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Sudden cardiac death in young athletes: preparticipation screening for underlying cardiovascular abnormalities and approaches to prevention
Sports Eligibility After Risk Assessment and Treatment in Children with Asymptomatic Ventricular Pre-excitation
The Electrocardiogram Is a Poor Diagnostic Tool to Detect Left Ventricular Hypertrophy in Children: A Comparison with Echocardiographic Assessment of Left Ventricular Mass
Finding the proverbial "needle in a haystack": identifying presymptomatic individuals with long QT syndrome
Community detection of long QT syndrome with a clinical registry: an alternative to ECG screening programs?
Cardiac imaging and stress testing asymptomatic athletes to identify those at risk of sudden cardiac death
Ventricular pre-excitation: symptomatic and asymptomatic children have the same potential risk of sudden cardiac death
Electrocardiogram Screening in Children with Congenital Sensorineural Hearing Loss: Prevalence and Follow-up of Abnormalities
Implementation of ultraportable echocardiography in an adolescent sudden cardiac arrest screening program
Regional Implementation of a Pediatric Cardiology Syncope Algorithm Using Standardized Clinical Assessment and Management Plans (SCAMPS) Methodology
Electrocardiographic and echocardiographic evaluation of a large cohort of peri-pubertal soccer players during pre-participation screening
Frequency of syncope as a presenting symptom in channelopathies diagnosed in childhood. Can the multivariable EGSYS score unmask these children?
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