Electrocardiographic and electrophysiologic effects of dexmedetomidine on children

Pacing and Clinical Electrophysiology : PACE
Yakup ErgulAlper Guzeltas

Abstract

Dexmedetomidine (DEX) is a highly selective alpha-2-adrenergic agonist approved for short-term sedation and monitored anesthesia care in adults. Its effects on the electrocardiography and cardiac conduction tissue are not well described in the literature. Therefore, we aimed to characterize the electrocardiographic and electrophysiologic effects of DEX in children. Twenty children (11 boys and nine girls) between the ages of eight and 17 undergoing electrophysiology study and ablation of the supraventricular tachycardia had hemodynamic and cardiac electrophysiologic variables measured before and during the administration of DEX (1 microgram/kg IV over 10 minutes followed by a 10-minute continuous infusion of 0.5 microgram/kg/h). A significant decrease in heart rate was seen after the administration of DEX, but the systolic-diastolic-mean arterial pressure, respiratory rate, and end-tidal carbon dioxide did not change. Corrected sinus node recovery times and baseline sinus cycle lengths, which are markers of sinus nodal function, were both lengthened with the administration of DEX. Atrioventricular (AV) nodal function, as evidenced by the Wenckebach cycle length, the ventriculoatrial block cycle length, and AV nodal effective re...Continue Reading

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Citations

Oct 26, 2016·Paediatric Anaesthesia·Christopher F TirottaRichard G Lagueruela
May 26, 2017·Current Opinion in Anaesthesiology·Cedric E Sottas, Brian J Anderson
Jan 4, 2017·International Journal of Clinical Pharmacy·Maowei GongQiang Fu
Jun 25, 2021·Journal of Pharmacy Practice·Katrin LichtsinnAlexandra Wilson
Jun 18, 2021·Circulation. Arrhythmia and Electrophysiology·Christopher M JansonMichael L O'Byrne

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