Abstract
Dexmedetomidine (DEX) is a highly selective alpha-2-adrenergic agonist approved for short-term sedation and monitored anesthesia care in adults. Its effects on the electrocardiography and cardiac conduction tissue are not well described in the literature. Therefore, we aimed to characterize the electrocardiographic and electrophysiologic effects of DEX in children. Twenty children (11 boys and nine girls) between the ages of eight and 17 undergoing electrophysiology study and ablation of the supraventricular tachycardia had hemodynamic and cardiac electrophysiologic variables measured before and during the administration of DEX (1 microgram/kg IV over 10 minutes followed by a 10-minute continuous infusion of 0.5 microgram/kg/h). A significant decrease in heart rate was seen after the administration of DEX, but the systolic-diastolic-mean arterial pressure, respiratory rate, and end-tidal carbon dioxide did not change. Corrected sinus node recovery times and baseline sinus cycle lengths, which are markers of sinus nodal function, were both lengthened with the administration of DEX. Atrioventricular (AV) nodal function, as evidenced by the Wenckebach cycle length, the ventriculoatrial block cycle length, and AV nodal effective re...Continue Reading
References
Jul 1, 1991·Anesthesiology·Y HayashiI Yoshiya
Nov 1, 1995·Anesthesiology·T KamibayashiI Yoshiya
Nov 1, 1995·Anesthesiology·T KamibayashiI Yoshiya
Feb 1, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Constantinos ChrysostomouRicardo Munoz
Jun 23, 2006·Anesthesia and Analgesia·Ahmed M MukhtarAmira M Hassona
Feb 3, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Joseph D Tobias
Jan 1, 2008·Anesthesia and Analgesia·Gregory B HammerAnne M Dubin
Oct 8, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kristin P BartonConstantinos Chrysostomou
Oct 22, 2008·Anesthesia and Analgesia·Constantinos ChrysostomouRicardo Munoz
Mar 10, 2010·Intensive Care Medicine·Constantinos ChrysostomouEdmund H Jooste
Aug 30, 2011·The Annals of Thoracic Surgery·Constantinos ChrysostomouVictor O Morell
Sep 13, 2011·Pediatric Cardiology·Joseph D TobiasAndrew R Yates
Jul 10, 2012·Annals of Cardiac Anaesthesia·Michelle LeRigerJoseph D Tobias
Mar 20, 2013·Paediatric Anaesthesia·Danton CharGregory B Hammer
Jun 28, 2013·World Journal for Pediatric & Congenital Heart Surgery·Sonya DelwadiaJoseph D Tobias
Oct 10, 2014·Annals of Pediatric Cardiology·Randhir S RajputBalram Airan
Citations
Oct 26, 2016·Paediatric Anaesthesia·Christopher F TirottaRichard G Lagueruela
Sep 23, 2016·Journal of Cardiovascular Pharmacology·Akinori SairakuYasuki Kihara
May 26, 2017·Current Opinion in Anaesthesiology·Cedric E Sottas, Brian J Anderson
Mar 23, 2018·Journal of Veterinary Pharmacology and Therapeutics·D S TrachselD A Klaerke
Apr 13, 2018·Anesthesia and Analgesia·Andrew M SlupePeter M Jessel
Nov 20, 2019·Anesthesia and Analgesia·Andrew M SlupePeter M Jessel
Jan 4, 2017·International Journal of Clinical Pharmacy·Maowei GongQiang Fu
Mar 3, 2021·BMC Anesthesiology·Qin YeXiaopei Gao
Jun 25, 2021·Journal of Pharmacy Practice·Katrin LichtsinnAlexandra Wilson
Jun 18, 2021·Circulation. Arrhythmia and Electrophysiology·Christopher M JansonMichael L O'Byrne