PMID: 8600754Mar 1, 1996Paper

Electrocardiographic changes and halofantrine plasma level during acute falciparum malaria

The American Journal of Tropical Medicine and Hygiene
J E TouzeJ C Doury

Abstract

The aim of this study was 1) to assess the incidence of electrocardiographic changes after treatment with halofantrine and 2) to study the relationship between these changes and plasma levels of halofantrine and its main metabolite, N-desbutyl-halofantrine. Thirty-four male patients with uncomplicated falciparum malaria were enrolled in this study. Halofantrine was administered on two separate days at a total oral dosage of 24 mg/kg/day in three doses over a 12-hr period. The interval between the two treatments was seven days. Twelve-lead electrocardiography (ECG) was performed to measure the QT interval (QTc), ambulatory ECG monitoring was done to detect ventricular arrhythmia, signal-averaged ECG was performed to detect late ventricular potentials, and blood tests were performed to determine plasma concentrations of halofantrine and N-desbutyl-halofantrine. Maximum QTc was observed at 12 hr after both the first (P < 0.0002) and second treatments (P < 0.03). Signal-averaged ECG revealed late potentials in four cases (72 hr after the first treatment in one case and 24 hr after the second treatment in three cases). Ventricular arrhythmia was not observed. Significantly higher plasma concentrations of halofantrine were observed 2...Continue Reading

Citations

Apr 12, 2001·British Journal of Clinical Pharmacology·D R AbernethyB G Schuster
Feb 27, 2003·Journal of Cardiovascular Pharmacology·Michelle P McIntoshSusan J Coker
Dec 16, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·A SowunmiL A Salako
Sep 24, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·A SowunmiA M Oduola
Jan 1, 1997·Scandinavian Journal of Infectious Diseases·S G GundersenG Edwards
Dec 18, 2003·British Journal of Clinical Pharmacology·Harin KarunajeewaTimothy M E Davis
Sep 26, 2000·Journal of Travel Medicine·D MalvyM Le Bras
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Sep 10, 2003·Journal of Travel Medicine·Olivier BouchaudJean P Coulaud
Feb 10, 2012·The Journal of Antimicrobial Chemotherapy·Pauline Byakika-KibwikaConcepta Merry
Jan 15, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·W Robert J Taylor, Nicholas J White
May 6, 2008·Infection·J SimkóI Lorincz
Jul 12, 2017·British Journal of Clinical Pharmacology·Palang ChotsiriJoel Tarning

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