Electrocardiographic changes and troponin T levels in children with severe malaria anemia and heart failure

Nigerian Journal of Clinical Practice
Wilson E Sadoh, J O Uduebor

Abstract

Severe malaria anemia is a major cause of childhood heart failure in malaria endemic countries. The resulting hypoxic-ischemic injuries may cause myocardial damage detectable by electrocardiogram (ECG) and elevated troponin T (cTnT) levels. Evaluate the ECG changes and cTnT levels in children with severe malaria anemia compared with those who had uncomplicated malaria without anemia. Consecutive children with severe malaria anemia were recruited as subjects while controls were age- and gender-matched children with uncomplicated malaria without anemia. ECG findings, cTnT levels, and the proportion of children with elevated cTnT were compared between subjects and controls. There were 43 subjects with a mean age of 25.7 ± 22.9 months. Controls were forty children; mean age was 31.2 ± 20.0 months. All the subjects and 10 (25.0%) controls had ECG abnormalities. Five (11.6%) subjects and no control had ST segment changes, P = 0.06. Twenty-three percent of subjects compared to 5% of the controls had prolonged QTc, P = 0.027. Median cTnT of subjects (131.8 ng/L) was not significantly higher than the 85.9 ng/L of controls, P = 0.99. The median cTnT of subjects that died 208.9 ng/L was higher than in survivors 99.6 ng/L, P = 0.51. Prolon...Continue Reading

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Citations

Nov 27, 2018·Journal of Physical Activity & Health·Kingsley K Akinroye, Ade F Adeniyi
Mar 11, 2020·BMC Nutrition·Adeleye Abiodun AdeomiDoyinfunmi Lydia Gbadegesin
Feb 27, 2021·Journal of the American College of Cardiology·Shyla GuptaAdrian Baranchuk

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