Electrocardiographic features of arrhythmogenic right ventricular dysplasia/cardiomyopathy according to disease severity: a need to broaden diagnostic criteria

Circulation
Khurram NasirHugh Calkins

Abstract

The purpose of this study was to systematically study diagnostic and prognostic electrocardiographic (ECG) characteristics of arrhythmogenic right ventricle dysplasia/cardiomyopathy (ARVD/C). The patient population included 50 patients with ARVD/C (27 males, 23 females; mean age 38+/-15 years). We also analyzed the ECG of 50 age- and gender-matched normal control subject and 28 consecutive patients who presented with right ventricular outflow tract (RVOT) tachycardia. Right bundle-branch block (RBBB) was present in 11 patients (22%). T-wave inversions in V1 through V3 were observed in 85% of ARVD/C patients in the absence of RBBB compared with none in RVOT and normal controls, respectively (P<0.0001); epsilon waves were seen in 33%, and a QRS duration > or =110 ms in V1 through V3 was present in 64% of patients. Among those without RBBB, our newly proposed criterion of "prolonged S-wave upstroke in V1 through V3" > or =55 ms was the most prevalent ECG feature (95%) and correlated with disease severity and induction of VT on electrophysiological study. This feature also best distinguished ARVD/C (diffuse and localized) from RVOT. A prolonged S-wave upstroke in V1 through V3 is the most frequent ECG finding in ARVD/C and should b...Continue Reading

References

Mar 12, 1999·Annual Review of Medicine·G FontaineR Frank
Jan 10, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Hirotsugu AtarashiUNKNOWN Idiopathic Ventricular Fibrillation Investigators
Sep 27, 2003·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Stefan Peters, Martina Trümmel

❮ Previous
Next ❯

Citations

Jul 4, 2009·Herz·Leif-Hendrik Boldt, Wilhelm Haverkamp
Feb 12, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Thomas HerrenFirat Duru
Mar 2, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·A AzaouaghR Erbel
Apr 3, 2007·Herzschrittmachertherapie & Elektrophysiologie·S Richter
Feb 7, 2006·Bratislavské lekárske listy·S NavarcikovaI Hulin
Nov 11, 2010·Current Treatment Options in Cardiovascular Medicine·Harsh C Patel, Hugh Calkins
Apr 3, 2008·Nature Clinical Practice. Cardiovascular Medicine·Mark M AwadDaniel P Judge
Dec 14, 2011·British Journal of Anaesthesia·R J IngN A Chambers
Nov 26, 2009·European Heart Journal·Domenico CorradoUNKNOWN Section of Sports Cardiology, European Association of Cardiovascular Prevention and Rehabilitation
May 16, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Etienne M AliotUNKNOWN Heart Rhythm Society
Mar 11, 2010·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Vy-Van LeVictor Froelicher
Jan 1, 2011·BMJ Case Reports·Constantinos O'MahonyAntonios Pantazis
Apr 15, 2008·Medicine and Science in Sports and Exercise·Christine E Lawless, Thomas M Best
Mar 28, 2008·Southern Medical Journal·Lakshminarayan YerraPratap Reddy
Nov 1, 2008·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Mauricio ArrudaAndrea Natale
Oct 12, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ganesh S KamathJonathan S Steinberg
Jan 1, 2013·Global Cardiology Science & Practice·Mohamed ElmaghawryMohammed Alhashemi
Dec 16, 2005·Current Opinion in Cardiology·Hugh Calkins
Jun 1, 2011·Indian Journal of Pediatrics·Sunit C SinghiGovindappa Benkatti
Aug 22, 2008·Current Cardiology Reports·Hugh Calkins, Frank Marcus
Aug 28, 2009·Current Cardiology Reports·Wendy S Tzou, Edward P Gerstenfeld
Mar 13, 2009·The New England Journal of Medicine·Angeliki AsimakiJeffrey E Saffitz
May 8, 2015·Expert Review of Cardiovascular Therapy·Julia Cadrin-TourignyPaul Khairy
Feb 6, 2008·Expert Review of Cardiovascular Therapy·Hicham Z El Masry, Anil V Yadav
May 11, 2010·Expert Review of Cardiovascular Therapy·Hamid GhanbariMarcos Daccarett
Mar 5, 2013·Current Problems in Cardiology·Hugh Calkins
Feb 28, 2016·Cardiac Electrophysiology Clinics·Marwan M RefaatMelvin Scheinman
Oct 30, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jane CaldwellAdrian Baranchuk
May 25, 2012·Revista Española De Cardiología·Giovanni Quarta, Perry M Elliott
Aug 30, 2011·Journal of Electrocardiology·Henry D Huang, Yochai Birnbaum
Feb 15, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Konstantinos P LetsasThomas Arentz
Jan 1, 2010·Compendium : Continuing Education for Veterinarians·Crystal D Hariu, Dewey H Carpenter
Aug 26, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Pyotr G PlatonovWojciech Zareba
Nov 6, 2009·Current Problems in Cardiology·Marco PerezVictor F Froelicher
May 8, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Harikrishna TandriHugh Calkins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Arrhythmogenic Right Ventricular Dysplasia

Arrhythmogenic right ventricular dysplasia is a congenital cardiomyopathy that is characterized by infiltration of adipose and fibrous tissue into the right ventricle wall and loss of myocardial cells. Primary injuries usually are at the free wall of the right ventricular and right atria resulting in ventricular and supraventricular arrhythmias. Discover the latest research on arrhythmogenic right ventricular dysplasia here.