Electrocardiographic transmural dispersion of repolarization in patients with inherited short QT syndrome.

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
Olli AnttonenMatti Viitasalo

Abstract

Short QT syndrome (SQTS) carries an increased risk for sudden cardiac death. However, only a short QT interval does not express the risk of ventricular arrhythmias. Thus, additional evaluation of the repolarization abnormality in SQTS patients is essential. In experimental models of SQTS, increased transmural dispersion of repolarization (TDR) and its electrocardiographic counterpart T-wave peak to T-wave end interval (TPE) appeared critical for induction of polymorphic ventricular tachycardia (PMVT). In a clinical study with acquired long QT syndrome patients, TPE/QT ratio > 0.28 indicated arrhythmia risk. We hypothesized that the TPE/QT ratio would be greater in SQTS patients than in control subjects. We compared the behavior of the electrocardiographic TDR in three seriously symptomatic SQTS patients of unknown genotype presenting baseline QTc values < 320 ms and in nine healthy age-matched control subjects. We determined QT and TPE intervals as well as TPE/QT ratio from 24-hour ECG recordings using a computer-assisted program. Diurnal average of TPE/QT ratio was 0.28 +/- 0.03 in SQTS patients and 0.21 +/- 0.02 in control subjects (P = 0.01). SQTS patients had also lesser capacity to change TPE intervals from steady-state co...Continue Reading

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Citations

Aug 19, 2010·Circulation. Arrhythmia and Electrophysiology·Chinmay PatelCharles Antzelevitch
Aug 12, 2015·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Keiko SonodaTohru Minamino
Nov 23, 2013·Current Problems in Cardiology·Indrajit ChoudhuriMasood Akhtar
Apr 22, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Matteo Vatta
Mar 9, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hiroshi WatanabeWataru Shimizu
Mar 5, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Sven ZumhagenEric Schulze-Bahr
Jun 6, 2009·Scandinavian Journal of Psychology·Niina Junttila, Marja Vauras
Oct 29, 2009·Human Mutation·Paula L HedleyMichael Christiansen
Jul 21, 2009·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Olli AnttonenHeikki V Huikuri
Feb 12, 2010·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Shlomo Stern
Oct 23, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Hiroshi SuzukiAkihiko Saitoh
Jul 26, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Philippe MauryAnne Rollin
Dec 7, 2010·Journal of Molecular and Cellular Cardiology·Yaxun SunGan-Xin Yan
Dec 2, 2008·Progress in Biophysics and Molecular Biology·Ian N SabirChristopher L-H Huang
Feb 12, 2011·Journal of the American College of Cardiology·Michael H GollobJason D Roberts
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Feb 19, 2015·Circulation. Arrhythmia and Electrophysiology·Manoj N ObeyesekereAndrew D Krahn
Aug 23, 2019·Journal of Cardiovascular Electrophysiology·Charles Antzelevitch
Jun 19, 2014·Experimental and Therapeutic Medicine·Lei RuanCuntai Zhang
Aug 25, 2015·World Journal of Clinical Cases·Yaniel Castro-TorresRichard E Katholi
Jan 29, 2019·European Heart Journal·Arie O Verkerk, Carol Ann Remme

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