Electrochemical and biological performance of chronically stimulated conductive hydrogel electrodes.

Journal of Neural Engineering
Ashley N DalrympleRobert K Shepherd

Abstract

Evaluate electrochemical properties, biological response, and surface characterization of a conductive hydrogel (CH) coating following chronic in vivo stimulation. Coated CH or uncoated smooth platinum (Pt) electrode arrays were implanted into the cochlea of rats and stimulated over a 5 week period with more than 57 million biphasic current pulses. Electrochemical impedance spectroscopy (EIS), charge storage capacity (CSC), charge injection limit (CIL), and voltage transient (VT) impedance were measured on the bench before and after stimulation, and in vivo during the stimulation program. Electrically-evoked auditory brainstem responses were recorded to monitor neural function. Following explant, the cochleae were examined histologically and electrodes were examined using scanning electron microscopy. CH coated electrodes demonstrated a bench-top electrochemical advantage over Pt electrodes before and after the electrical stimulation program. In vivo, CH coated electrodes also had a significant advantage over Pt electrodes throughout the stimulation program, exhibiting higher CSC (p= 0.002), larger CIL (p = 0.002), and lower VT impedance (p < 0.001). The CH cohort exhibited a greater tissue response (p= 0.003) with small deposi...Continue Reading

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Citations

Oct 24, 2020·Biomaterials Science·Richard VoXiaocheng Jiang
Feb 13, 2021·Journal of Neural Engineering·Robert K ShepherdJames B Fallon
Oct 30, 2020·Neuron·Giuseppe SchiavoneStéphanie P Lacour
May 22, 2021·Acta Biomaterialia·Poppy Oldroyd, George Malliaras
Oct 16, 2021·Journal of Neural Engineering·Ashley N DalrympleDouglas J Weber
Jul 27, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Douglas M BennionMarlan R Hansen

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