Electrochemical aspects of electrospray and laser desorption/ionization for mass spectrometry

Annual Review of Analytical Chemistry
Mélanie AbonnencHubert H Girault

Abstract

Soft-ionization methods, namely electrospray ionization and laser desorption/ionization, are widely used to transfer large molecules as intact gas-phase ions either from a solution or from a solid substrate. During both processes, in-source electrochemical and photoelectrochemical reactions occur. These electrode reactions, which take place at interfaces, play important roles in influencing the ionization products, but they have received little attention. We show that having good control over both types of electrochemical reactions can lead to new analytical applications. Examples include online tagging by grafting of mass tags and in-source photooxidation of peptides.

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Citations

Aug 11, 2012·Analytical Chemistry·Liang QiaoHubert H Girault
Mar 3, 2012·Enfermedades infecciosas y microbiología clínica·Elena Jordana-LluchVicente Ausina Ruiz
Sep 10, 2015·Journal of Mass Spectrometry : JMS·Yury KostyukevichEugene Nikolaev
Dec 18, 2013·Mass Spectrometry Reviews·Herbert OberacherSabine Plattner
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Apr 1, 2018·Mass Spectrometry Reviews·Yury KostyukevichEugene Nikolaev
Feb 17, 2018·Journal of the American Society for Mass Spectrometry·Bradley B Stocks, Jeremy E Melanson
May 17, 2012·Angewandte Chemie·Atif ElahiDaren J Caruana
Nov 7, 2018·Analytical and Bioanalytical Chemistry·Bradley B Stocks, Jeremy E Melanson
Mar 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Margaux FresnaisRémi Longuespée
Apr 15, 2020·Analytical Chemistry·Jie SunZongxiu Nie

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Methods Mentioned

BETA
electrophoresis
chip
electron-capture dissociation

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