Electrochemical cell for separation of [18F]fluoride from irradiated 18O-water and subsequent no carrier added nucleophilic fluorination

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Kurt HamacherHeinz H Coenen

Abstract

An electrochemical cell was designed allowing the anodic deposition of n.c.a. [18F]fluoride solubilized in an 18O-water target and subsequent n.c.a. nucleophilic 18F-fluorination. The recovery of the deposited [18F]fluoride can be achieved in the presence of an aprotic solvent containing a phase-transfer catalyst (PTC). The radioisotope adsorbed electrochemically at the cylindrical surface of a glassy carbon electrode can be dried easily by washing the cell twice with dry aprotic solvents while maintaining a low electric field. This simple washing step makes an azeotropic drying process obsolete. Accordingly, less basic cryptates like [K within 2.2.2.]oxalate or triflate can be used for nucleophilic 18F-fluorination because loss of activity as a consequence of azeotropic drying under conditions of low basicity does not occur. The usefulness of this technique is exemplified for the n.c.a. synthesis of various 18F-labelled compounds. The radiotracers were synthesized with higher radiochemical yields and under much easier conditions than the conventional 18F-fluorination procedure which includes an additional drying step of the PTC.

References

Jan 1, 1990·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·D J SchlyerA P Wolf
Jan 1, 1989·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·D AlexoffA P Wolf

❮ Previous
Next ❯

Citations

Mar 12, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Saman SadeghiR Michael van Dam
Jun 8, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Ping HeStephen J Archibald
Jun 2, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Fabian KüglerHeinz H Coenen
Jan 12, 2016·Chemical Reviews·Sean PreshlockVéronique Gouverneur
Mar 2, 2010·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Hidekazu SaikiEiichi Ozeki
Mar 9, 2007·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Fuminori SaitoToshio Hyodo
Oct 9, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Andreas HelferHeinz H Coenen
Nov 3, 2010·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·A SvadbergO K Hjelstuen
May 21, 2013·Nuclear Medicine and Biology·Giancarlo PascaliPiero A Salvadori
Jul 26, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Christian RenschBjörn Wängler
Aug 24, 2018·Chemical Communications : Chem Comm·A PeesD J Vugts
Apr 27, 2019·Journal of Labelled Compounds & Radiopharmaceuticals·Johannes ErmertHeinz H Coenen
Jun 1, 2014·Lab on a Chip·Christian RenschBjörn Wängler
Nov 23, 2010·Organic & Biomolecular Chemistry·Johnny Castillo MeleánHeinz H Coenen
Sep 18, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Franziska M WagnerHeinz H Coenen
May 20, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Daniel Hernández-Valdés, Saman Sadeghi

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
D AlexoffA P Wolf
Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Kurt Hamacher, Heinz H Coenen
Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
F SaitoT Hyodo
European Journal of Nuclear Medicine and Molecular Imaging
Hans-Jürgen WesterGjermund Henriksen
Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Rebecca WongEiichi Ozeki
© 2022 Meta ULC. All rights reserved