Electrochemical DNA-Based Sensors for Molecular Quality Control: Continuous, Real-Time Melamine Detection in Flowing Whole Milk

Analytical Chemistry
Hui LiKevin W Plaxco

Abstract

The ability to monitor specific molecules in real-time directly in a flowing sample stream and in a manner that does not adulterate that stream could greatly augment quality control in, for example, food processing and pharmaceutical manufacturing. Because they are continuous, reagentless, and able to work directly in complex samples, electrochemical DNA-based (E-DNA) sensors, a modular and, thus, general sensing platform, are promising candidates to fill this role. In support, we describe here an E-DNA sensor supporting the continuous, real-time measurement of melamine in flowing milk. Using target-driven DNA triplex formation to generate an electrochemical output, the sensor responds to rising and falling melamine concentration in seconds without contaminating the product stream. The continuous, autonomous, real-time operation of sensors such as this could provide unprecedented safety, convenience, and cost-effectiveness relative to the batch processes historically employed in molecular quality control.

References

Nov 30, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Rebecca Y LaiKevin W Plaxco
Apr 24, 2009·Journal of Agricultural and Food Chemistry·Lisa J MauerReeta Davis
Jun 25, 2009·Analytical Chemistry·Massimiliano CuccioloniMauro Angeletti
Mar 6, 2010·Accounts of Chemical Research·Arica A Lubin, Kevin W Plaxco
Nov 26, 2010·Trends in Biotechnology·Kevin W Plaxco, H Tom Soh
Dec 29, 2011·Journal of the American Chemical Society·Yingying ZengDennis Bong
May 12, 2012·Biosensors & Bioelectronics·Shuang HanGuobao Xu
Oct 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Anna J SimonKevin W Plaxco
Dec 18, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Florika C MacazoRyan J White
May 14, 2016·The Analyst·Chunmei GuHanchang Shi
Aug 27, 2016·Accounts of Chemical Research·Francesco RicciKevin W Plaxco
Dec 15, 2016·Journal of the American Chemical Society·Hui LiKevin W Plaxco
Apr 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jacob Somerson, Kevin W Plaxco

❮ Previous
Next ❯

Citations

Apr 17, 2020·International Journal of Molecular Sciences·Hirotaka MinagawaIwao Waga
Jul 15, 2020·Nature Materials·Qian LiChengde Mao
Jan 16, 2021·ACS Applied Materials & Interfaces·Yingzhu LiuYi Xiao
Jan 14, 2021·ACS Sensors·Yi PengRichard M Crooks
Apr 2, 2021·Journal of the American Chemical Society·Amanda CliffordShana O Kelley
Jul 4, 2020·ACS Sensors·Claudio ParoloKevin W Plaxco

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.