Electrochemical fabrication of reduced MoS2 -based portable molecular imprinting nanoprobe for selective SERS determination of theophylline

Mikrochimica Acta
Yuan-Ting LiSheng Han

Abstract

A new portable molecular imprinting polymer (MIP)-SERS nanoprobe is fabricated by a convenient electrochemical method. Single-layered MoS2 is electrochemically reduced on a screen-printed electrode as the scaffold. Functional monomers o-phenylenediamine (oPD), template theophylline (THP), and SERS-active Au nanoparticles (AuNPs) are then one-step electropolymerized on the scaffold. The morphology of the nanoprobe is found to be a three-dimensional and porous structure. The abundant AuNPs with the size of 45~50 nm are trapped within the growing MIP instead of being confined to the surface. The thickness of MIP film is calculated to 25.1 nm. The nanoprobe displays a strong SERS effect for THP using 532 nm as excitation wavelength with a detection limit (LOD) of 0.01 nM. The SERS peak intensity at 1487 cm-1 increases linearly with the concentration of THP in the range 0.1 nM to 0.1 mM. After the template is removed, the imprint-removed nanoprobe is generated for selective binding of THP. The re-binding kinetics study implies the portable MIP-SERS nanoprobe can reach the adsorption equilibrium within 8 min. This nanoprobe exhibits low SERS interference for structural analogues theobromine (THB) and caffeine (CAF). The nanoprobe was...Continue Reading

References

Jul 14, 2010·Biosensors & Bioelectronics·Keren KantarovichIlana Bar
Nov 1, 2011·Nano Letters·Goki EdaManish Chhowalla
Mar 8, 2014·The Analyst·Tiancheng WangCraig E Banks
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Oct 7, 2014·Chemical Communications : Chem Comm·Shaona ChenJingyao Qi
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