Electrochemical investigation into the redox activity of Fe(II)/Fe(III) in the presence of nicotine and possible relations to neurodegenerative diseases

Biochimica Et Biophysica Acta
M H BridgeW Linert

Abstract

The biological relevance of Fe(II)/Fe(III) is becoming evermore apparent, especially in relation to its potential role in the progression of neurodegenerative diseases such as Parkinson's and Alzheimer's disease. The reported relationship between smoking and a reduced incidence of neurodegenerative disorders prompted this work. In order to investigate whether nicotine can interact with iron, we have studied the electrochemical behaviour of a Fe(II)/Fe(III) redox couple in the presence of nicotine. Solubility issues and lack of available nonreacting salts of nicotine necessitated studies being conducted at low pH values. Cyclic voltammetry experiments revealed a definite alteration in the electrochemical behaviour of the Fe(II)/Fe(III) redox couple suggesting the capability of nicotine to complex with free iron and, hence, reduce its reactivity. This is evident from a slower rate of heterogeneous electron transfer, ks, and a shift from reversible to quasi-reversible behaviour, as characterised from the diffusion coefficient (D), the full width half maximum (FWHM), DeltaEp and Ef. Additional complexation titrations, pH ranging from 1 to 7, confirm a weak complexation reaction occurring between Fe(III) and nicotine.

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Citations

Jul 8, 2009·International Journal of Molecular Sciences·Yahya E ChoonaraSibongile R Sibambo
Jan 26, 2010·Expert Opinion on Drug Delivery·Ndidi NgwulukaDinesh Naidoo
Aug 5, 2008·Neurobiology of Disease·Shannon L Rhodes, Beate Ritz
Jan 9, 2008·Neuroscience and Biobehavioral Reviews·Concepcion Conejero-GoldbergLuis Ulloa
Mar 23, 2007·European Journal of Pharmacology·Dariusz PogockiElzbieta Wałajtys-Rode
Sep 10, 2014·Environmental Research·Marcin DelijewskiEwa Buszman
Aug 14, 2012·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Yijun WangRichard G Compton
Jun 15, 2019·Journal of Bioenergetics and Biomembranes·Dominika MalińskaJoanna Szczepanowska
Apr 26, 2021·Journal of Proteomics·José Navarrete-PereaJoao A Paulo

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