Electrochemical investigation of the chloride effect on hemoglobin

Bioelectrochemistry
Yuting SunGenxi Li

Abstract

Direct electron transfer between hemoglobin and gold electrode is achieved at both a bare and a 4, 4'-bipyridine-modified gold electrode in the presence of chloride ions. The addition of chloride to hemoglobin solution also increases the reversibility of the direct electrochemistry and shifts the formal potential of hemoglobin to the negative direction. While the existence of chloride does not significantly change the tertiary structure of the protein, it might induce a slight variation of the structure, which is beneficial to the electrochemical response. It is suggested that the chloride binding to hemoglobin is a combination of specific and unspecific bindings.

References

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Citations

Apr 17, 2007·Journal of Biosciences·S Rezaei-ZarchiA Javed
Dec 17, 2009·Analytical Biochemistry·Zhibin MaiXiaoyong Zou
Nov 12, 2013·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Jianbo LiuQinglin Sheng
Sep 21, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Sheng-Fu WangKwok-Yin Wong

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