Electrochemical monitoring of piroxicam in different pharmaceutical forms with multi-walled carbon nanotubes paste electrode

Journal of Pharmaceutical and Biomedical Analysis
Abdolkarim Abbaspour, Roya Mirzajani

Abstract

The electrochemical behavior of piroxicam on a multi-walled carbon nanotubes electrode for the first time was investigated. A highly sensitive and fast responding sensor for determination of piroxicam was simply and conveniently fabricated. The constructed electrode exhibits efficiently catalytic activity for the electrooxidation of piroxicam at a reduced over potential with high sensitivity, stability, and long lifetime in the wide concentration rang of piroxicam. The oxidation process was found to be dependent on the pH of the supporting electrolyte. The behavior is further exploited as a sensitive detection method for piroxicam determination by differential pulse voltammetry. Under the optimized conditions the calibration plots are linear in the concentration range of 0.15-5 microg ml(-1). Application of the method for the determination of the drug in the dosage form (Feledene capsules and tablets and also piroxicam gel), without any interference, from the excipients, resulted in acceptable deviation from the stated concentrations. Recoveries were obtained in the range 96.35-104.16%. The detection limit of 0.1 microg ml(-1) was obtained for piroxicam determination.

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Citations

Jul 8, 2008·Analytica Chimica Acta·Lourdes AgüíJosé M Pingarrón
Jan 1, 2009·Sensors·A J Saleh AhammadMd Aminur Rahman
Aug 27, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mustafa ÇeşmeIbrahim Demirtaş
Sep 28, 2010·Analytical Biochemistry·Vinod K GuptaShilpi Agarwal
Nov 10, 2015·Ultrasonics Sonochemistry·Simone Vieira PereiraLuis Alexandre Pedro de Freitas
Apr 14, 2015·Jundishapur Journal of Natural Pharmaceutical Products·Nadereh RahbarAhmad Babapour
Apr 30, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Jessica OtarolaPatricia G Molina

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