Electrochemical paper based cancer biosensor using iron oxide nanoparticles decorated PEDOT:PSS

Analytica Chimica Acta
Saurabh KumarBansi Dhar Malhotra

Abstract

We report results of the studies relating to the fabrication of a label-free, flexible, light weight and disposable conducting paper based immunosensing platform comprising of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) and nanostructured iron oxide (nFe2O3@PEDOT:PSS) nanocomposite for detection of carcinoembryonic antigen (CEA), a cancer biomarker. The effect of various solvents such as sorbitol, ethanol, propanol, n-methyl-2-pyrrolidone (NMP) and dimethyl sulfoxide (DMSO) on the electrical conductivity of Whatman filter paper (WP) modified with nFe2O3@PEDOT:PSS/WP was investigated. The electrical conductivity of the PEDOT:PSS/WP electrode was found to be enhanced by two orders of magnitude (from 6.8× 10-4 to 1.92 × 10-2 Scm-1) after its treatment with DMSO. Further, nFe2O3 doped PEDOT:PSS/WP electrode exhibited the electrical conductivity as 2.4 × 10-2 Scm-1. Besides this, the incorporation of iron oxide nanoparticles (nFe2O3) into PEDOT:PSS/WP resulted in improved electrochemical performance and signal stability. This nFe2O3@PEDOT:PSS/WP based platform was used for immobilization of the anti-carcinoembronic antigen (anti-CEA) protein for quantitative estimation of cancer biomarker (CEA). The results of electroche...Continue Reading

Citations

Nov 30, 2019·Chemical Communications : Chem Comm·Ehsan Nazarzadeh ZareVinod V T Padil
Jul 11, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jinho YoonJeong-Woo Choi
Oct 1, 2020·Journal of Functional Biomaterials·John H T LuongBansi D Malhotra
Apr 17, 2020·Micromachines·Jennifer QuinchiaJahir Orozco
Apr 13, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Raymond Christopher Setiawan, D Y Li
May 1, 2021·Biosensors·Domingo R Flores-HernandezJaime Bonilla-Rios
Apr 22, 2021·Lab on a Chip·Wen-Chin LeeLung-Ming Fu
Jun 1, 2021·Journal of Colloid and Interface Science·Russell J WilsonChun-Xia Zhao

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