Electrochemical study of the anticancer drug daunorubicin at a water/oil interface: drug lipophilicity and quantification

Analytical Chemistry
José A RibeiroCarlos M Pereira

Abstract

In this work, the ion transfer mechanism of the anticancer drug daunorubicin (DNR) at a liquid/liquid interface has been studied for the first time. This study was carried out using electrochemical techniques, namely cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The lipophilicity of DNR was investigated at the water/1,6-dichlorohexane (DCH) interface, and the results obtained were presented in the form of an ionic partition diagram. The partition coefficients of both neutral and ionic forms of the drug were determined. The analytical parameter for the detection of DNR was also investigated in this work. An electrochemical DNR sensor is proposed by means of simple ion transfer at the water/DCH interface, using DPV as the quantification technique. Experimental conditions for the analytical determination of DNR were established, and a detection limit of 0.80 μM was obtained.

References

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Aug 1, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Francine KivlehanDamien W M Arrigan
Oct 1, 2010·Physical Chemistry Chemical Physics : PCCP·José A RibeiroCarlos M Pereira

Citations

Sep 28, 2019·Critical Reviews in Analytical Chemistry·Masoumeh GhalkhaniSibel A Ozkan
Jan 1, 2019·Critical Reviews in Analytical Chemistry·Sevinc KurbanogluSibel A Ozkan

Related Concepts

Antibiotics, Cytotoxic
Daunorubicin Hydrochloride
Oils
Electrochemical Techniques
Antigens, Differentiation
Antineoplastic Agents
Ions
Cyclic Peptides
Daunorubicinol
Drug Interactions

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