Electrochemically Promoted Fluoroalkylation-Distal Functionalization of Unactivated Alkenes

Organic Letters
Zhenlei ZouYi Pan

Abstract

Difunctionalization of olefins represents a powerful synthetic tool and yet a challenging task. This work describes an electrochemically enabled fluoroalkylation-migration reaction of unactivated olefins in the absence of a strong oxidant or heavy metal catalyst, affording fluorinated (hetero)aryl ketones in good yields and excellent regioselectivities. The efficient and sustainable electrochemical strategy provides a rapid access to a dual functionalized fluorine-containing heterocyclic manifold.

References

Jun 23, 2006·Chemical Society Reviews·Jeffrey B Sperry, Dennis L Wright
May 24, 2008·Chemical Society Reviews·Tomislav Pintauer, Krzysztof Matyjaszewski
Jun 21, 2008·Chemical Reviews·Jun-ichi YoshidaAiichiro Nagaki
May 11, 2013·Chemical Communications : Chem Comm·Yu-Dong YangNorio Shibata
May 18, 2013·Chemical Communications : Chem Comm·Yu-Tao HeYong-Min Liang
Feb 7, 2014·Chemical Society Reviews·Robert Francke, R Daniel Little
May 3, 2014·Chemical Society Reviews·Estíbaliz Merino, Cristina Nevado
Mar 31, 2015·Chemical Communications : Chem Comm·Pan XuChengjian Zhu
May 9, 2015·Chemical Society Reviews·Zhi-Min ChenYong-Qiang Tu
Apr 20, 2016·Organic & Biomolecular Chemistry·Chen-Chen Li, Shang-Dong Yang
May 18, 2016·The Journal of Organic Chemistry·Yang RanFeng-Ling Qing
Dec 10, 2016·Journal of the American Chemical Society·Fei WangGuosheng Liu
Jan 6, 2017·The Journal of Organic Chemistry·Zhong-Quan Liu, Dong Liu
Feb 16, 2017·Journal of the American Chemical Society·Peng XiongHai-Chao Xu
Aug 12, 2017·Science·Niankai FuSong Lin
Oct 11, 2017·Journal of the American Chemical Society·Niankai FuSong Lin
Nov 18, 2017·Chemical Science·Xinjun Tang, Armido Studer
Nov 23, 2017·Angewandte Chemie·Xinjun Tang, Armido Studer
Jan 6, 2018·Journal of the American Chemical Society·Chaohuang ChenGuosheng Liu
Feb 7, 2018·Journal of the American Chemical Society·Peng XiongHai-Chao Xu
Feb 7, 2018·Journal of the American Chemical Society·Ke-Yin YeSong Lin
May 31, 2018·Journal of the American Chemical Society·Xiaoxu QiGuosheng Liu
Jun 21, 2018·Chemical Communications : Chem Comm·Yonghui HeGanpeng Li
Aug 23, 2018·Journal of the American Chemical Society·Liang FuGuosheng Liu
Aug 30, 2018·Journal of the American Chemical Society·Kohki M NakafukuDavid A Nagib
Sep 13, 2018·Chemistry : a European Journal·Yongyuan GaoYi Pan

❮ Previous
Next ❯

Citations

Sep 24, 2020·Organic & Biomolecular Chemistry·Chengkou LiuKai Guo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.