PMID: 10408Oct 1, 1976

Electrochemistry of drug action I: electrooreduction of ferredoxins

Journal of Pharmaceutical Sciences
Y W Chien

Abstract

Ferredoxin serves as an electron carrier in the oxidation-reduction system in anaerobic microorganisms, transferring electrons from a low potential donor to electron-accepting biochemicals. The anaerobicidal activity of some drugs may be due to their interference with the electron transport function of ferredoxin. Two types of ferredoxins (isolated from Clostridium pasteurianum and spinach) were studied, and their electrochemical reduction and biochemical properties were analyzed using a sensitive ac polarographic technique. The reduction potential of both ferredoxins was linearly related to pH. The mechanisms of electron transport in ferredoxin molecules were found to be related to their sulfur-iron bonds. The dissociation of the sulfur-iron bonds resulted in the formation of a free sulfhydryl group and the interruption of the electroactivity of ferredoxin. This sulfur-iron dissociation process was found to be pH dependent. The electroreduction of ferredoxins was an energy-requiring, pH-dependent process.

References

Jun 1, 1975·Journal of Pharmaceutical Sciences·Y W ChienD R Sanvordeker
May 1, 1974·Biochemical Pharmacology·R M IngsW E Ormerod
Dec 1, 1968·The Biochemical Journal·M C EvansF R Whatley
May 1, 1973·Journal of General Microbiology·D I EdwardsH Carne
Sep 1, 1971·Analytical Biochemistry·P D.J. Weitzman, H J Tyler

Citations

Aug 28, 1987·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H L Schmidt, H Günther

Related Concepts

Clostridium
Copper Cystinate
Electrochemistry
Respiratory Chain
Ethylmaleimide
Ferredoxin II
Hydrogen-Ion Concentration
Iron
Oxidation-Reduction
Pulse Polarography

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