Electrochemotherapy in combination with chemoradiotherapy in the treatment of oral carcinomas in advanced stages of disease: efficacy, safety, and clinical outcomes in a small number of selected cases

Drug Design, Development and Therapy
Rossana DomanicoEugenia Allegra

Abstract

Electrochemotherapy (ECT) is a new therapeutic method that is used in oncology as palliative treatment in patients with recurrent head and neck tumors and who are not candidates for standard therapeutic options. The aim of our study was to evaluate the cytoreductive effect of ECT in patients subjected to chemoradiotherapy for squamous cell carcinoma of the oral cavity. The primary endpoint of the study was to verify tumor debulking after ECT treatment as neoadjuvant, before conventional chemoradiotherapy. The secondary endpoint was to assess the safety and tolerability of ECT treatment. This experimental study was conducted at the Division of Otolaryngology, University of Catanzaro, Italy. From February 2013 to February 2014, four patients were enrolled, two males and two females, with a mean age of 56 years (range: 47-65 years), and with squamous cell carcinoma of the oral cavity in advanced stages of disease (T3-T4). All patients, with their informed consent, received ECT treatment in accordance with the Standard Operating Procedures defined in the European Standard Operating Procedures on Electrochemotherapy (ESOPE) study, followed by conventional chemoradiotherapy. Their response to ECT treatment was assessed after 30 days....Continue Reading

Citations

Aug 22, 2018·Oncology Letters·Armando De VirgilioAntonio Greco
Feb 6, 2019·Journal of Healthcare Engineering·Nazila Esmaeili, Michael Friebe
Feb 17, 2021·Acta Oto-laryngologica·Corinna E ZimmermannJörg Wiltfang

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