Electrochemotherapy of Spinal Metastases Using Transpedicular Approach-A Numerical Feasibility Study

Technology in Cancer Research & Treatment
Helena CindričD Miklavcic

Abstract

Vertebral column is the most frequent site for bone metastases. It has been demonstrated in previous studies that bone metastases can be efficiently treated by electrochemotherapy. We developed a novel approach to treat spinal metastases, that is, transpedicular approach that combines electrochemotherapy with already established technologies for insertion of fixation screws in spinal surgery. In the transpedicular approach, needle electrodes are inserted into the vertebral body through pedicles and placed around the tumor. The main goal of our study was to numerically investigate the feasibility of the proposed treatment approach. Three clinical cases were used in this study-1 with a tumor completely contained within the vertebral body and 2 with tumors spread also to the pedicles and spinal canal. Anatomically accurate numerical models were built for all 3 cases, and numerical computations of electric field distribution in tumor and surrounding tissue were performed to determine the treatment outcome. Complete coverage of tumor volume with sufficiently high electric field is a prerequisite for successful electrochemotherapy. Close to 100% tumor coverage was obtained in all 3 cases studied. Two cases exhibited tumor coverage of...Continue Reading

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Citations

Sep 23, 2020·Artificial Organs·Maurício Martins TaquesDaniela Ota Hisayasu Suzuki
Dec 1, 2019·Bioelectricity·Maja Cemazar, Gregor Sersa

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

3D
Slicer
Comsol Multiphysics
Matlab

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