Electrochemotherapy treatment of a recalcitrant earlobe keloid scar with chronic lymphocytic leukaemia infiltration

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS
D C G SainsburyT Muir

Abstract

Electrochemotherapy, a tumour ablation modality, which facilitates intracellular delivery of poorly-permeable cytotoxic drugs, such as bleomycin, has shown promising results in the treatment of cutaneous and subcutaneous melanomatous and non-melanomatous metastases. We report the case of a 52-year-old Caucasian gentleman with a keloid scar to his left earlobe that developed following a piercing. Despite multiple intralesional steroidal injections, five intralesional excisions and a course of superficial radiotherapy the keloid scar remained over nine years later. For 15 years the patient had also suffered chronic lymphocytic leukaemia with no nodal disease or systemic involvement. However, histological analysis of the final surgical excision specimen showed chronic lymphocytic leukaemia infiltration of the keloid scar. Further surgical excision seemed unwise considering the recalcitrance of the keloid scar. Additionally, no systemic chemotherapy treatment options were feasible. Electrochemotherapy was performed under local anaesthesia with the aim of eradicating the chronic lymphocytic leukaemia deposit within the keloid lesion. Four sessions of electrochemotherapy using bleomycin were deployed over 11 months. A deep core biops...Continue Reading

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Citations

May 19, 2012·Case Reports in Surgery·Lindsay M FishJames M Lewis
Feb 24, 2017·SAGE Open Medical Case Reports·Ali RaufiYehuda Lebowicz
Oct 1, 2013·Plastic and Reconstructive Surgery·Giorgio MancaFrancesca de Terlizzi
Apr 1, 2021·Dermatology : International Journal for Clinical and Investigative Dermatology·Hanne FalkJulie Gehl

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