Electroconformational denaturation of membrane proteins

Annals of the New York Academy of Sciences
Wei Chen

Abstract

Because of high electrical impedance of cell membrane, when living cells are exposed to an external electric field, the field-induced voltage drops will mainly occur on the cell membrane. In addition to Joule heating damage and electroporation of the cell membrane, the electric field-induced supraphysiological transmembrane potential may inevitably damage the membrane proteins, especially the voltage-dependent membrane proteins. That is because the charged particles in the amino acid of the membrane proteins and, in particular, the voltage-sensors in the voltage-dependent membrane proteins are vulnerable to the membrane potential. An intensive, brief electric shock may induce electroconformational damage or denaturation in the membrane proteins. As a result, the cell functions are significantly reduced. This electric field-induced denaturation in the membrane proteins strongly suggests a new underlying mechanism involved in electrical injury.

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Citations

Sep 18, 2013·Journal of Burn Care & Research : Official Publication of the American Burn Association·Nicholas J PrindezeJeffrey W Shupp
Jun 20, 2007·European Biophysics Journal : EBJ·J-M EscoffreC Favard
Aug 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Debabrata MishraClaudio Fontanesi
Nov 19, 2011·Tissue Engineering. Part C, Methods·Alastair Khodabukus, Keith Baar
Nov 26, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thibaut Brunet, Detlev Arendt
Apr 28, 2016·The Hastings Center Report·John Hoberman
Feb 29, 2020·Journal of Cardiovascular Electrophysiology·Christopher J Bradley, David E Haines
Feb 27, 2020·Bioengineering·Nasim NosoudiPaul Turner
Jul 28, 2018·Chemical Reviews·Martin P StewartKlavs F Jensen

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