Electroconvulsive shock alters the rat overt rhythms of motor activity and temperature without altering the circadian pacemaker

Behavioural Brain Research
Montserrat Anglès-PujolràsT Cambras

Abstract

The hypothetical relationship between circadian rhythms alterations and depression has prompted studies that examine the resultant effects of various antidepressants. Electroconvulsive therapy (ECT) exerts significant antidepressant effects that have been modelled in the laboratory via the use of electroconvulsive shock (ECS) in rats. However, data on the effects of ECT or ECS vis-à-vis the circadian rhythms remain scarce. Thus, we report here the effects of acute and chronic ECS administration on the temperature and motor activity circadian rhythms of rats. The motor activity and core body temperature of rats were continuously recorded to determine the circadian rhythms. We carried out three experiments. In the first, we analyzed the effects of acute ECS on both the phase and period when applied at different times of the subjective day. In the second and third experiments ECS was nearly daily applied to rats for 3 weeks: respectively, under dim red light, which allows a robust free-running circadian rhythm; and under light-dark cycles of 22 h (T22), a setting that implies dissociation in the circadian system. Acute ECS does not modify the phase or the period of circadian rhythms. Chronic administration of ECS produces an incre...Continue Reading

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Citations

Sep 3, 2011·Brain Research·Anthony L GotterJohn J Renger
Aug 7, 2013·Journal of Receptor and Signal Transduction Research·Peter Kovacic, Ratnasamy Somanathan
Apr 21, 2012·Journal of Affective Disorders·Mauro García-ToroMiguel Roca
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Oct 2, 2012·Revista de psiquiatrí́a y salud mental·Mauro García-ToroMiguel Roca
Jul 27, 2010·Chronobiology International·Wytske A HofstraAl W De Weerd

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