Electroconvulsive therapy improves antipsychotic and somnographic responses in adolescents with first-episode psychosis--a case-control study

Schizophrenia Research
Zhang-Jin ZhangQing-Rong Tan

Abstract

Previous studies have demonstrated the effectiveness of electroconvulsive therapy (ECT) in pharmacotherapy-resistant neuropsychiatric conditions. This study aimed to evaluate the efficacy and safety of ECT in adolescents with first-episode psychosis. This case-control study was conducted in inpatients aged 13-20 years with first-episode psychosis. Every three similar age and same gender patients consecutively recruited were randomly allocated to control and ECT group at a ratio of 1:2, while they had antipsychotic treatment. ECT treatment was performed for 3 sessions per week with a maximum of 14 sessions. The endpoint was discharge from hospital. Clinical outcomes were measured using hospital stay days, the Positive and Negative Syndrome Scale (PANSS) and response rate. Polysomnography (PSG) was conducted at baseline and at week 2. Safety and tolerability were also evaluated. Between March 2004 and November 2009, 112 eligible patients were allocated to control (n=38) and ECT (n=74) group. Additional ECT treatment significantly reduced hospital stay compared to controls (23.2±8.2 days versus 27.3±9.3 days, mean±SD, P=0.018). Survival analysis revealed that the ECT-treated group had a significantly higher cumulative response rat...Continue Reading

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Citations

Sep 27, 2015·Clinical Psychology Review·Sarah ReeveDaniel Freeman
Jul 15, 2015·Psychiatry and Clinical Neurosciences·Asli SarandolMelehat Dirican
Sep 4, 2014·European Child & Adolescent Psychiatry·Itziar FlamariqueJosefina Castro-Fornieles
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Dec 7, 2018·Acta Neuropsychiatrica·Sandeep GroverRaman Koirala
Mar 4, 2020·Journal of Child and Adolescent Psychopharmacology·Neera GhaziuddinMohammad Ghaziuddin

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