Electroconvulsive Therapy Induces Cortical Morphological Alterations in Major Depressive Disorder Revealed with Surface-Based Morphometry Analysis

International Journal of Neural Systems
Jinping XuKai Wang

Abstract

Although electroconvulsive therapy (ECT) is one of the most effective treatments for major depressive disorder (MDD), the mechanism underlying the therapeutic efficacy and side effects of ECT remains poorly understood. Here, we investigated alterations in the cortical morphological measurements including cortical thickness (CT), surface area (SA), and local gyrification index (LGI) in 23 MDD patients before and after ECT. Furthermore, multivariate pattern analysis using linear support vector machine (SVM) was applied to investigate whether the changed morphological measurements can be effective indicators for therapeutic efficacy of ECT. Surface-based morphometry (SBM) analysis found significantly increased vertex-wise and regional cortical thickness (CT) and surface area (SA) in widespread regions, mainly located in the left insula (INS) and left fusiform gyrus, as well as hypergyrification in the left middle temporal gyrus (MTG) in MDD patients after ECT. Partial correlational analyses identified associations between the morphological properties and depressive symptom scores and impaired memory scores. Moreover, SVM result showed that the changed morphological measurements were effective to classify the MDD patients before an...Continue Reading

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Citations

Jun 9, 2020·International Journal of Neural Systems·Roberto Sánchez-ReolidAntonio Fernández-Caballero
Dec 24, 2020·International Journal of Neural Systems·Yongjie ZhuFengyu Cong
Mar 16, 2021·Cerebral Cortex·Yanlu WangIvanka Savic
Jun 7, 2021·Neuroscience and Biobehavioral Reviews·Anne Margarette S MaalloScott A Holmes

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