Electrocortical and behavioral effects of chronic immobility on word processing

Brain Research. Cognitive Brain Research
B KotchoubeyNiels Birbaumer

Abstract

Neuroelectrical and subjective effects of chronic motor deficits (severe immobility) on word processing were explored. A total of ten artificially ventilated patients with end-stage amyotrophic lateral sclerosis (ALS), seven patients with tetraplegia due to a high spinal cord injury (SCI), and nine matched controls were examined. Both ALS and SCI patients were almost completely paralyzed; eye, head, and face movements were intact in SCI but not in ALS patients. Event-related brain potentials (ERPs) were recorded during presentation of verbs with strong motor-action associations and nouns with strong visual associations. Subjects estimated the subjective strength of motor and visual associations for each word using a scale from 0 to 5. No between-group difference was found for subjectively rated motor associations. All patients reported much stronger visual associations for both nouns and verbs than healthy subjects. ERPs to both word classes revealed a left occipital negativity in SCI patients at a latency of 200-300 ms, and a marked decrease of the slow positive wave in the interval of 300-800 ms in the two patient groups. Both psychophysical and electrophysiological data suggest compensatory activation of visual information p...Continue Reading

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Citations

Jun 25, 2005·Journal of Neurology·Dorothée LuléSilke Anders
May 13, 2010·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Chiara VolpatoNiels Birbaumer
Dec 3, 2014·Brain and Cognition·Boris Kotchoubey, Sylvain El-Khoury
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Mar 25, 2008·Neuroscience Letters·Yutaka FuchinoTakeshi Yoro
Feb 16, 2005·IEEE Transactions on Bio-medical Engineering·Thilo HinterbergerNiels Birbaumer
Oct 4, 2011·Journal of Neuroscience Methods·A FurdeaN Birbaumer
Feb 5, 2013·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Ilario LazzaroAshley Craig

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