Electrocortical and Biochemical Evaluation of Antidepressant Efficacy of Formulated Nanocurcumin

Applied Biochemistry and Biotechnology
Haitham S MohammedHanaa M Amer

Abstract

The present study aims to evaluate the antidepressant efficacy of curcumin nanoparticles on rat model of depression induced by reserpine. Rats were divided into control, the rat model of depression induced by daily i.p. injection of reserpine (0.2 mg/kg for 21 days), and the rat model of depression treated daily with the formulated CNPs (20 mg/kg for 7 and 15 days). The behavioral evaluation was assessed for all groups of animals by the forced swim test (FST). Monoamine neurotransmitters were measured in the cortex and hippocampus via fluorescence spectroscopy. The electrophysiological evaluation was carried out by recording and analyzing the electrocorticogram (ECoG) in a group of animals that served as self-control. The chronic administration of reserpine resulted in a significant decrease in the duration of the active phase in the FST; a significant decrease in the cortical and hippocampal levels of serotonin, norepinephrine, and dopamine; a significant increase in spectral power of alpha and delta waves; and a significant decrease in spectral power of theta, beta-1, and beta-2 waves with respect to control values. Administration of CNPs for 7 days has improved the performance of animals in FST indicated by the increase in t...Continue Reading

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Citations

Dec 18, 2020·Frontiers in Psychiatry·Tahiana RamaholimihasoArthur Kaladjian
Mar 7, 2021·The Australian and New Zealand Journal of Psychiatry·Julia Novaes MatiasSandra Maria Barbalho
Apr 22, 2021·Neurotoxicology·Yasser A KhadrawyHaitham S Mohammed
Jul 30, 2021·European Journal of Pharmacology·Yasser A KhadrawyHaitham S Mohammed

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