Electrode positioning for reliable telemetry ECG recordings during social stress in unrestrained rats

Physiology & Behavior
A SgoifoE Musso

Abstract

We describe a surgical procedure for optimizing the location of telemetry ECG leads in rats. The new location was aimed at obtaining an accurate representation of ECG features throughout the cardiac cycle by limiting the voltage instability usually observed during intense somatomotor activity and improving the signal-to-noise ratio. The two electrodes (wire loops) were fixed on the dorsal surface of the xiphoid process and in the anterior mediastinum close to the right atrium. The implantation procedure was fast, little invasive, and allowed animals to completely recover from intervention. The performance of the "improved" location (IL, n = 10) with respect to two subcutaneous (SC) positionings ("conventional positioning" CSP, n = 5; "updated location," USL, n = 5) was evaluated by comparing ECGs obtained in baseline, stress and recovery conditions and during different behavioral activities (immobility and grooming). The resident-intruder test (emotional/physical challenge) was chosen as experimental stress paradigm. The noise level of ECGs obtained from IL rats was lower than in CSP and USL animals, in all recording conditions. Percentages of correctly recognized beats (CRBs) over the total number of beats (TBs) were significa...Continue Reading

Citations

Jul 5, 2001·Physiology & Behavior·A SgoifoE Musso
Oct 22, 2003·Physiology & Behavior·Alessandro BartolomucciAndrea Sgoifo
Dec 2, 1999·Neuroscience and Biobehavioral Reviews·A SgoifoP Meerlo
Apr 1, 1999·Journal of Pharmacological and Toxicological Methods·A M DeveneyD M Jackson
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Feb 1, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Aimen K FarrajWayne E Cascio
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Apr 14, 2010·Physiology & Behavior·Muammar M KabirEugene Nalivaiko
Dec 17, 2009·European Journal of Pharmacology·Jocelien D A OlivierBart A Ellenbroek
Nov 11, 2008·Physiology & Behavior·Eugene NalivaikoAndrea Sgoifo
Sep 6, 2008·Neuroscience and Biobehavioral Reviews·Francesca MastorciAndrea Sgoifo
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Jan 12, 2005·Physiology & Behavior·Jelly G de JongJaap M Koolhaas
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