Electroencephalographic and Electrocardiographic Effect of Intravenous Lacosamide in Refractory Focal Epilepsy

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
Chin-Wei W HuangRichard S McLachlan

Abstract

Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels to achieve seizure reduction. We studied the effect of intravenous lacosamide given as one of three single doses on EEG and electrocardiogram, as well as its tolerability in patients with drug-resistant epilepsy. This Canadian, investigator-initiated, multicenter, double-blind study recruited patients with refractory focal epilepsy admitted to a seizure monitoring unit. Participants received a loading dose of 100, 200, or 400 mg lacosamide over 30 minutes during continuous monitoring by video-EEG and 12-lead electrocardiogram. The number of interictal spikes, frequency and quantity of background EEG rhythms, corrected QT interval (QTc), PR interval, heart rate (HR), blood pressure, and respiration rate during 60 minutes before the administration were compared with 60 minutes after the infusion. We documented any adverse event during and after the infusion. Seventy-one patients completed the study. There was a significant decrease in interictal spikes (P = 0.039) and decreased frequency of the alpha rhythm (P = 0.003). No significant difference in beta, theta, and delta frequency or amount was noted. There were significant increases in PR interval...Continue Reading

References

May 1, 1987·Epilepsia·J S Duncan
Mar 1, 1994·Electroencephalography and Clinical Neurophysiology·M C SalinskyL Morehead
Dec 8, 2004·Epilepsy & Behavior : E&B·M C SalinskyD Storzbach
Aug 4, 2006·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Warren T Blume
Apr 28, 2007·CNS Drug Reviews·Bettina K BeyreutherThomas Stöhr
Jan 1, 2010·Epilepsia·Gregory KraussUNKNOWN SP757 Study Group
Feb 6, 2010·Epilepsia·Steve ChungUNKNOWN SP754 Study Group
Jan 25, 2011·CNS Drugs·Linda J Stephen, Martin J Brodie
Aug 16, 2016·Epilepsy & Behavior : E&B·Kimford J MeadorElizabeth Webster

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Citations

Jul 1, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ali A Asadi-PooyaIman Karimzadeh
Jan 9, 2020·Expert Opinion on Drug Safety·Jiyuan LiXuefeng Wang
Jul 16, 2021·Epilepsy Research·Hyun Kyung KimDong Wook Kim
Dec 24, 2021·Expert Opinion on Drug Safety·Gaetano ZaccaraFrancesco Brigo

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