Electroencephalographic and histological characteristics of a model of limbic status epilepticus permitting direct control over seizure duration

Epilepsy Research
M Gruenthal

Abstract

Status epilepticus is a neurological emergency associated with substantial morbidity and mortality. Experimental and clinical investigations suggest that prolonged seizure activity is associated with injury to vulnerable neurons. Compounds with neuroprotective properties may minimize such injury. Existing methods of inducing experimental status epilepticus result in seizure activity of variable duration and neuronal injury of variable degree. To minimize such variability, status epilepticus may be stopped with anticonvulsants, but this limits the ability to screen for independent neuroprotective properties. We have developed a simple and reliable non-pharmacological model of limbic status epilepticus in which the duration of status epilepticus is under direct experimental control. Status epilepticus is induced by continuous, unilateral hippocampal stimulation. Using this model, the degree of hippocampal pyramidal cell injury varies in direct proportion to status epilepticus duration across a range of 15-140 min. A progressive sequence of EEG changes unfolds with increasing status epilepticus duration, resembling that seen in other models. This model may serve as a reference against which the effects of potential neuroprotective...Continue Reading

References

Nov 1, 1977·Electroencephalography and Clinical Neurophysiology·K H TaberS F Zornetzer
Jan 1, 1991·Neuroscience·R Schmidt-Kastner, T F Freund
Jan 1, 1992·Epilepsia·C M DeGiorgioD M Treiman
Jul 1, 1989·Acta Neurologica Scandinavica·C Y Sung, N S Chu
Jun 1, 1987·Experimental Neurology·J P Vicedomini, J V Nadler
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Oct 28, 1982·Brain Research·D C McIntyreN Edson
Jul 1, 1995·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·N B Fountain, E W Lothman
Jul 1, 1995·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·D M Treiman
Nov 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H Li, A M Buchan
May 1, 1993·Epilepsy Research·A Handforth, R F Ackermann
Jun 1, 1993·Brain Research. Molecular Brain Research·M DragunowP Gluckman
Mar 1, 1993·Neurology·D H Lowenstein, B K Alldredge

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