PMID: 3748323Jul 1, 1986Paper

Electroencephalographic (EEG), EEG power spectra, and behavioral correlates in rats given phencyclidine

Neuropharmacology
A Mattia, J E Moreton

Abstract

The electroencephalogram (EEG), electromyogram (EMG) and behavior were monitored in rats with chronic cerebrocortical and temporalis muscle electrodes. They were injected acutely with 0, 2, 4 and 8 mg/kg of phencyclidine (i.p.). The EEG power spectra correlated in a dose-related manner, with the direct EEG and behavioral effects of phencyclidine. At 2 mg/kg, the EEG consisted primarily of low amplitude theta activity from 6 to 8 Hz, accompanied by behavioral arousal and hyperactivity. At 4 mg/kg, the EEG theta activity persisted and was superimposed on a background of high amplitude slow waves which were associated with the emergence of ataxia. Locomotion and stereotypy intensified at this dose. The power spectra of these changes in the EEG were characterized by two distinct spectral peaks lying between 0-5 and 5-10 Hz. After 8 mg/kg, EEG activity shifted predominantly to lower frequencies between 2 and 3 Hz. This shift produced a large increase in spectral power in the 0-5 Hz band which was accompanied behaviorally by severe ataxia, limited locomotion, and stereotypy of head and forepaw movements. Similarities and differences between these EEG changes induced by phencyclidine and the EEG effects of ketamine and SKF 10047 were ...Continue Reading

Citations

Aug 1, 1995·Pharmacology, Biochemistry, and Behavior·C Coltro Campi, G D Clarke
Jun 6, 1986·Neuroscience Letters·W S Lai, E E el-Fakahany
Apr 3, 2008·The Journal of Comparative Neurology·Jun LuClifford B Saper
Jul 19, 2013·Journal of Psychopharmacology·Mark J Hunt, Stefan Kasicki
May 7, 2020·Reviews in the Neurosciences·Rebecca McMillan, Suresh D Muthukumaraswamy
Dec 13, 2016·Journal of Psychiatric Research·Luis Rafael Leite SampaioSilvânia Maria Mendes de Vasconcelos

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