Electroencephalographic features of convulsive epilepsy in Africa: A multicentre study of prevalence, pattern and associated factors

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Symon M KariukiSEEDS investigators

Abstract

We investigated the prevalence and pattern of electroencephalographic (EEG) features of epilepsy and the associated factors in Africans with active convulsive epilepsy (ACE). We characterized electroencephalographic features and determined associated factors in a sample of people with ACE in five African sites. Mixed-effects modified Poisson regression model was used to determine factors associated with abnormal EEGs. Recordings were performed on 1426 people of whom 751 (53%) had abnormal EEGs, being an adjusted prevalence of 2.7 (95% confidence interval (95% CI), 2.5-2.9) per 1000. 52% of the abnormal EEG had focal features (75% with temporal lobe involvement). The frequency and pattern of changes differed with site. Abnormal EEGs were associated with adverse perinatal events (risk ratio (RR)=1.19 (95% CI, 1.07-1.33)), cognitive impairments (RR=1.50 (95% CI, 1.30-1.73)), use of anti-epileptic drugs (RR=1.25 (95% CI, 1.05-1.49)), focal seizures (RR=1.09 (95% CI, 1.00-1.19)) and seizure frequency (RR=1.18 (95% CI, 1.10-1.26) for daily seizures; RR=1.22 (95% CI, 1.10-1.35) for weekly seizures and RR=1.15 (95% CI, 1.03-1.28) for monthly seizures)). EEG abnormalities are common in Africans with epilepsy and are associated with prev...Continue Reading

References

Jan 1, 1995·Magnetic Resonance Imaging·D R Fish, S S Spencer
Apr 1, 1996·Brain : a Journal of Neurology·O C CockerellS D Shorvon
Feb 24, 2001·Archives of Disease in Childhood·J CrawleyF Kirkham
Feb 5, 2003·Seizure : the Journal of the British Epilepsy Association·David HolderColin Binnie
Mar 23, 2004·American Journal of Epidemiology·Guangyong Zou
Feb 6, 2008·Lancet Neurology·Manish SadaranganiCharles R Newton
Oct 18, 2011·Epilepsia·David J ThurmanUNKNOWN ILAE Commission on Epidemiology
Oct 25, 2011·Journal of Child Neurology·Jo M WilmshurstCharles R Newton
Feb 14, 2012·Archives of Disease in Childhood·Samson GwerCharles R Newton
Mar 15, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marc R Nuwer
Oct 2, 2012·Lancet·Charles R Newton, Hector H Garcia
Sep 28, 2013·The American Journal of Emergency Medicine·Shahriar ZehtabchiArthur C Grant
May 31, 2014·PLoS Neglected Tropical Diseases·Gathoni KamuyuUNKNOWN Study of Epidemiology of Epilepsy in Demographic Sites (SEEDS) group
Apr 5, 2015·Neurology·Symon M KariukiUNKNOWN SEEDS Writing Group

❮ Previous
Next ❯

Software Mentioned

STATA

Related Concepts

Related Feeds

ALS: Transposon de-silencing

Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.

Related Papers

PLoS Neglected Tropical Diseases
Gathoni KamuyuStudy of Epidemiology of Epilepsy in Demographic Sites (SEEDS) group
Revista médica del Hospital General
J HUMBERTO MATEOSR RAMOS RAMIREZ
Revista médica del Hospital General
J H MATEOSR RAMOS RAMIREZ
© 2021 Meta ULC. All rights reserved