Electroencephalographic sleep profiles in treatment course and long-term outcome of major depression: association with DEX/CRH-test response

Journal of Psychiatric Research
Martin HatzingerEdith Holsboer-Trachsler

Abstract

Altered electroencephalographic (EEG) sleep patterns are among the most prominent neurobiological findings in depression. Several of these alterations have been suggested to be associated with an unfavorable long-term outcome. However, the impact of pathological sleep parameters on a more recurrent course of illness or vice versa still warrants clarification. Underlying mechanisms may involve systems known to be related to both sleep regulation and long-term course of depression such as the hypothalamic-pituitary-adrenocortical (HPA) axis. Thus, EEG sleep profiles of patients with depression were examined to determine whether (1) the retrospective clinical course of depression, and (2) the prospective long-term outcome in follow-up are associated with EEG sleep parameters. To elucidate related mechanisms HPA system functioning was evaluated by using the combined DEX/CRH test. Fifteen patients with affective disorders who participated in an earlier controlled antidepressant treatment study over 6 weeks were consecutively enrolled in an exploratory follow-up study. The retrospective analysis revealed that during the acute state of depression predominantly sleep continuity measures were associated with the number of previously exp...Continue Reading

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Citations

May 28, 2008·European Archives of Psychiatry and Clinical Neuroscience·Elisabeth FriessMarcus Ising
Apr 1, 2010·European Archives of Psychiatry and Clinical Neuroscience·Serge BrandEdith Holsboer-Trachsler
Jul 5, 2011·Behavioral Sleep Medicine·Holly J RamsawhMurray B Stein
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Nov 6, 2013·Pharmacology & Therapeutics·M DreslerF Holsboer
Oct 25, 2013·International Review of Psychiatry·Sebastian Olbrich, Martijn Arns
Jun 12, 2008·Industrial Health·Serge BrandEdith Holsboer-Trachsler
Apr 20, 2011·Journal of Psychiatric Research·Zuzana LattovaThomas Pollmächer
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Feb 24, 2006·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Jianhua ShenColin M Shapiro
Feb 3, 2019·International Journal of Molecular Sciences·Axel Steiger, Marcel Pawlowski

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