PMID: 1197895Jan 1, 1975Paper

Electrolyte changes in myocardial injury

Recent Advances in Studies on Cardiac Structure and Metabolism
E Urbánek Pospísil

Abstract

The shifts in the myocardial electrolyte metabolism during secondary or primary cardiopathies in dogs and rats, respectively, are described. Major attention is paid to the changes of Ca in the myocardial tissue. The increase in the Ca level after ligation of ramus circumflex of the left coronary artery, or after F-COL + Na2HPO4, and vitamin D2 administration, is regarded as a triggering process for more profound successive changes in the metabolism of the myocardial cell, which eventually lead to depletion of the high energy phosphate reserves. In the dogs with experimental coronary occlusion, the normalization of the myocardial ionogram, i.e., the ratio of K, Na, Ca, and Mg, was achieved by means of the mechanical heart assist, using the original design of the blood pump, where bypass and counterpulsation principles work simultaneously. The normalization of the Ca level in this case was achieved on the basis of a marked reduction of the volume work of the left ventricle, which is secured by the bypass component; on the other hand, the counterpulsation component of the combined pump secures the reduction of pressure work placed upon the left ventricle (represented by the decrease fo the end-diastolic pressure) and helps in the ...Continue Reading

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.