Electrolyte imbalances in pediatric living related small bowel transplantation

Transplantation
Ulf H BeierEunice John

Abstract

Pediatric small bowel transplantations are associated with pronounced electrolyte disturbances in the postoperative period. We investigated the pattern of electrolyte disturbances with regard to enteral malabsorption, renal compensation, and the influence of immunosuppression. We reviewed 11 small bowel transplantations between October 2002 and February 2007. The data collected included frequent serum, ostomy, and urine electrolyte profiles, renal function parameters, and FK 506 levels in the postoperative period up until either discharge or graft loss. Our results show enteral losses most prominent during the first 4 weeks postoperatively that are only partially compensated by the kidneys. Subsequently, enteral losses improved, although renal function remained challenged, particularly glomerular filtration and phosphorus, magnesium losses, which correlated with high FK 506 levels. Our data reveal several electrolyte imbalances different and unique to postoperative small bowel transplants. Although enteral losses improve along with graft villi formation, electrolyte abnormalities continue, to which FK 506-mediated renal toxicity might contribute.

References

Oct 1, 1996·Kidney International·T F AndohW M Bennett
Jan 9, 1998·Transplantation·F S ShihabT F Andoh
Jun 17, 1998·The American Journal of Medicine·M A Rodino, E Shane
Mar 31, 1999·American Journal of Therapeutics·R A PrestonM D Oster HR
Aug 9, 2003·Pflügers Archiv : European journal of physiology·Claudia A BertuccioFernando R Ibarra
Oct 19, 2004·Journal of Bone and Mineral Metabolism·Shiho KirinoToshio Sugahara
Sep 27, 2005·Transplantation Proceedings·S FaenzaA Pinna
Jan 28, 2006·Biochemical and Biophysical Research Communications·Shang-Jin KimGary A Quamme
Jun 27, 2006·Transplantation Proceedings·S D NavaneethanR D Monk
Sep 14, 2006·Current Gastroenterology Reports·Stephen J D O'Keefe, Laura Matarese
Oct 7, 2006·Current Opinion in Gastroenterology·K R Prasad, S G Pollard
Oct 25, 2006·Annals of Surgery·Enrico BenedettiGiuliano Testa

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Citations

Apr 8, 2009·Current Opinion in Organ Transplantation·Girish L Gupte, Susan V Beath
Aug 20, 2009·Clinical Transplantation·Gang JiGuanglong Dong
Apr 25, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

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