Electrolyte type and nozzle composition affect the process of vibrating-membrane nebulization

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Moritz Beck-Broichsitter, Nina Oesterheld

Abstract

The size of airborne particles determines their deposition pattern within the lungs and therefore, the efficacy of inhalation therapy. The present study analyzed factors affecting liquid atomization performed by vibrating-membrane technology. First, the process of vibrating-membrane nebulization (eFlow®rapid and Aeroneb® Pro) was challenged with numerous inorganic salts and active pharmaceutical ingredients. All investigated samples caused a sigmoidal decrease in aerosol droplet size upon an increase in concentration. Calculated dose-effect curve characteristics (i.e., half maximal effective sample concentration inducing a halfway drop of the droplet size) indicated distinct molar "potency" amongst the utilized samples with respect to generation of "adequate" inhalation aerosols. Second, the employed solvent (aqueous vs. organic) was shown to amplify the electrolyte effect on vibrating-membrane technology (i.e., dose-effect curve characteristics and overall aerosol droplet size). Third, besides the sample and solvent type, the nozzle composition (diverse metal and polymer coatings) induced a strong impact on the current mode of nebulization. Here, coating materials were identified, which necessitated higher and lower electrolyt...Continue Reading

Citations

Oct 16, 2019·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Per GerdeEwa Selg
Oct 21, 2020·Pharmaceutics·Hui-Ling LinZi Yi Chiang
Sep 2, 2019·Journal of Pharmaceutical Sciences·Moritz Beck-Broichsitter
Aug 29, 2021·Pharmaceutics·Waiting TaiPhilip Chi Lip Kwok

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