PMID: 6978687Mar 1, 1982Paper

Electrolyte versus blood cardioplegia: randomized clinical and myocardial ultrastructural study

The Annals of Thoracic Surgery
A K SinghE Karlson

Abstract

In 40 consecutive patients undergoing coronary artery bypass, one of two solutions for cardioplegia, each containing 30 mEq/L of K+ was used randomly. The groups were comparable except for intramyocardial temperature. With electrolyte solution (Group A), it was 16.5 degrees +/- 0.34 degrees C, while with blood from the pump-oxygenator (Group B) it was 20.3 degrees +/- 0.41 degrees C (p less than 0.001). After bypass left atrial pressure (LAP) was 11.9 +/- 0.67 torr in Group A and 8.1 +/- 0.49 torr in Group B (p less than 0.001). CPK-MB was elevated in 45% of Group A patients versus 15% in Group B (p less than 0.05). No patient died. Two myocardial infarctions occurred in Group A and one in Group B. Stereological morphometric electron microscopy was performed on biopsy specimens taken from the left ventricle (1) before perfusion, (2) after cardioplegia, and (3) 30 minutes after reperfusion. Group A showed marked intracellular edema, mitochondrial swelling, pronounced depletion of glycogen stores, and focal myofibrillary disorganization. Group B showed near normal myocardial ultrastructure with increased glycogen stores and minimal mitochondrial swelling. Morphometric analysis revealed a statistically significant increase in the ...Continue Reading

References

Jan 1, 1979·The Annals of Thoracic Surgery·V W Fischer, H B Barner
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Citations

Jul 1, 1988·Biulleten' eksperimental'noĭ biologii i meditsiny·I F Egorova, Iu V Popov
Aug 1, 1995·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·S F KatircioğluK Bayazit
Oct 1, 1995·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·J T ChristensonM Schmuziger
May 1, 1983·Journal of the American College of Cardiology·E R Rosenkranz, G D Buckberg
Nov 1, 1985·Journal of the American College of Cardiology·A K SinghK E Karlson
Feb 1, 1985·The Annals of Thoracic Surgery·J E CoddV L Willman
May 1, 1987·Progress in Cardiovascular Diseases·N A Silverman, S Levitsky
Dec 22, 2005·The Annals of Thoracic Surgery·Shinichi MizutaniJennifer S Lawton
Jul 1, 1998·The Annals of Thoracic Surgery·I G DuarteR A Guyton
Apr 1, 1987·The Annals of Thoracic Surgery·K H TeohR J Baird
Dec 1, 1991·The Annals of Thoracic Surgery·H B Barner
Jun 1, 1989·The Journal of Surgical Research·R W IllesS Levitsky
Apr 1, 1989·The Australian and New Zealand Journal of Surgery·M NewmanF L Rosenfeldt
Sep 1, 1986·Journal of Cardiac Surgery·A S WechslerJ P Goldstein
Mar 1, 1987·The Journal of Surgical Research·K G WarnerS F Khuri

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