Electrolytic Effects During Tissue Ablation by Electroporation

Technology in Cancer Research & Treatment
Liel RubinskyBoris Rubinsky

Abstract

Nonthermal irreversible electroporation is a new tissue ablation technique that consists of applying pulsed electric fields across cells to induce cell death by creating permanent defects in the cell membrane. Nonthermal irreversible electroporation is of interest because it allows treatment near sensitive tissue structures such as blood vessels and nerves. Two recent articles report that electrolytic reaction products at electrodes can be combined with electroporation pulses to augment and optimize tissue ablation. Those articles triggered a concern that the results of earlier studies on nonthermal irreversible electroporation may have been tainted by unaccounted for electrolytic effects. The goal of this study was to reexamine previous studies on nonthermal irreversible electroporation in the context of these articles. The study shows that the results from some of the earlier studies on nonthermal irreversible electroporation were affected by unaccounted for electrolysis, in particular the research with cells in cuvettes. It also shows that tissue ablation ascribed in the past to irreversible electroporation is actually caused by at least 3 different cytotoxic effects: irreversible electroporation without electrolysis, irreve...Continue Reading

References

Aug 1, 1968·Biochimica Et Biophysica Acta·A J Sale, W A Hamilton
May 3, 2000·Bioelectrochemistry·E NilssonJ M Olsson
Aug 3, 2002·The British Journal of Surgery·B G FoshG J Maddern
Jun 19, 2003·Physiological Measurement·Dieter HaemmerichJ G Webster
Nov 25, 2003·ANZ Journal of Surgery·Beverley G FoshGuy J Maddern
Mar 18, 2005·Annals of Biomedical Engineering·R V DavalosB Rubinsky
Nov 19, 2005·Technology in Cancer Research & Treatment·Liron MillerBoris Rubinsky
Jan 24, 2007·Technology in Cancer Research & Treatment·Boris RubinskyPaul Mikus
Aug 3, 2007·Technology in Cancer Research & Treatment·Boris Rubinsky
Aug 3, 2007·Technology in Cancer Research & Treatment·Gary OnikBoris Rubinsky
May 1, 2008·PloS One·Yair GranotBoris Rubinsky
Oct 28, 2008·The Journal of Urology·Jonathan RubinskyBoris Rubinsky
Aug 18, 2009·The Journal of Urology·Ryan J HalterKeith D Paulsen
Mar 2, 2010·Biomedical Engineering Online·Alex Golberg, Boris Rubinsky
Jul 2, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Kevin P CharpentierDamian E Dupuy
Nov 21, 2012·Archives of Surgery·Kevin P Charpentier
Aug 10, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Robert C G Martin
Jan 18, 2014·Seminars in Interventional Radiology·Govindarajan NarayananKatuska Barbery
Nov 13, 2014·IEEE Transactions on Bio-medical Engineering·Chunlan JiangJohn Bischof

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Citations

May 6, 2016·Annals of Biomedical Engineering·Mary PhillipsBoris Rubinsky
Mar 19, 2016·Scientific Reports·Claudia MuratoriOlga N Pakhomova
Jul 28, 2019·Journal of Cardiovascular Electrophysiology·René van EsKars Neven
Sep 29, 2020·Technology in Cancer Research & Treatment·Hong Bae Kim, Jong Hoon Chung
Jul 16, 2017·Biomedical Microdevices·Chenang LyuBoris Rubinsky
Apr 25, 2018·Cardiovascular and Interventional Radiology·Alette H RuarusMartijn R Meijerink
Jan 6, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wojciech SzlasaJulita Kulbacka
Feb 18, 2020·Bioelectrochemistry·Nina KleinAntoni Ivorra
Mar 19, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Chenang LyuTammy T Chang
Oct 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vitalij NovickijIrutė Girkontaitė
Jul 31, 2021·Trends in Cardiovascular Medicine·Luigi Di BiaseJorge Romero
Sep 21, 2021·Circulation. Arrhythmia and Electrophysiology·Atul VermaRobert E Neal

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