Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage

Biochemical and Biophysical Research Communications
Sanetaka ShirahataYoshinori Katakura

Abstract

Active oxygen species or free radicals are considered to cause extensive oxidative damage to biological macromolecules, which brings about a variety of diseases as well as aging. The ideal scavenger for active oxygen should be 'active hydrogen'. 'Active hydrogen' can be produced in reduced water near the cathode during electrolysis of water. Reduced water exhibits high pH, low dissolved oxygen (DO), extremely high dissolved molecular hydrogen (DH), and extremely negative redox potential (RP) values. Strongly electrolyzed-reduced water, as well as ascorbic acid, (+)-catechin and tannic acid, completely scavenged O.-2 produced by the hypoxanthine-xanthine oxidase (HX-XOD) system in sodium phosphate buffer (pH 7.0). The superoxide dismutase (SOD)-like activity of reduced water is stable at 4 degrees C for over a month and was not lost even after neutralization, repeated freezing and melting, deflation with sonication, vigorous mixing, boiling, repeated filtration, or closed autoclaving, but was lost by opened autoclaving or by closed autoclaving in the presence of tungsten trioxide which efficiently adsorbs active atomic hydrogen. Water bubbled with hydrogen gas exhibited low DO, extremely high DH and extremely low RP values, as d...Continue Reading

Citations

Mar 2, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kuo-Chin HuangChiang-Ting Chien
Apr 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Masaaki NakayamaSadayoshi Ito
Jan 5, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Wan-Jun ZhuSadayoshi Ito
Mar 1, 2012·BMC Proceedings·Sanetaka ShirahataKiichiro Teruya
Feb 3, 2007·Biological & Pharmaceutical Bulletin·Mi-Ja KimHye Kyung Kim
Jan 8, 2008·Biological & Pharmaceutical Bulletin·Jun YeSanetaka Shirahata
Mar 3, 2009·Biological & Pharmaceutical Bulletin·Kyu Jae LeeDong Heui Kim
Oct 15, 2010·Bioscience, Biotechnology, and Biochemistry·Hanxu YanSanetaka Shirahata
Jun 12, 2008·Journal of Clinical Biochemistry and Nutrition·Fujitoshi SengaSeiji Shioda
Jan 24, 2006·Bioscience, Biotechnology, and Biochemistry·Dan JinKyu Jae Lee
Jul 9, 2011·Bioscience, Biotechnology, and Biochemistry·Hanxu YanSanetaka Shirahata
Nov 11, 2014·Oxidative Medicine and Cellular Longevity·Taichi KashiwagiSanetaka Shirahata
Dec 10, 2008·Drug Development and Industrial Pharmacy·Toshihiko KitamuraKenji Sugibayashi
Aug 19, 2008·Biochemical and Biophysical Research Communications·Yasunori SatoAkihito Ishigami
Jul 10, 2004·Letters in Applied Microbiology·B S M MahmoudT Suzuki
Jun 20, 2007·Hemodialysis International·Masaaki NakayamaSadayoshi Ito
Jan 22, 2011·Clinical and Experimental Pharmacology & Physiology·Xing-Feng ZhengZhao-Fan Xia
Nov 28, 2013·Hemodialysis International·Hiroyuki TerawakiMasaaki Nakayama
May 16, 2014·BioMed Research International·Keliang XieGuolin Wang
Feb 28, 2013·Food Chemistry·Yusheng ZhaoXiaodan Wang
Jul 13, 2013·Journal of Hazardous Materials·Weiti CuiWenbiao Shen
May 17, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yang-Suk YoonKyu-Jae Lee
Apr 18, 2015·Nephro-urology Monthly·Yoshihiro TangeShigenori Yoshitake
Jan 8, 2014·Research in Sports Medicine·Sergej M Ostojic, Marko D Stojanovic
Jun 25, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Massimiliano MagroFabio Vianello
Dec 24, 2013·Life Sciences·Mengyuan ZhengMuralikrishnan Dhanasekaran

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