Electromechanical coupling of waves in nerve fibres

Biomechanics and Modeling in Mechanobiology
Jüri EngelbrechtKert Tamm

Abstract

The propagation of an action potential (AP) in a nerve fibre is accompanied by mechanical and thermal effects. In this paper, an attempt is made to build up a mathematical model which couples the AP with a possible pressure wave (PW) in the axoplasm and waves in the nerve fibre wall (longitudinal-LW and transverse-TW) made of a lipid bilayer (biomembrane). A system of differential equations includes the governing equations of single waves with coupling forces between them. The single equations are kept as simple as possible in order to carry out the proof of concept. An assumption based on earlier studies is made that the coupling forces depend on changes (the gradient, time derivative) of the voltage. In addition, it is assumed that the transverse displacement of the biomembrane can be calculated from the gradient of the LW in the biomembrane. The computational simulation is focused to determining the influence of possible coupling forces on the emergence of mechanical waves from the AP. As a result, an ensemble of waves (AP, PW, LW, TW) emerges. The further experiments should verify assumptions about coupling forces.

References

Nov 1, 1973·Zeitschrift Für Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie·W Helfrich
Jun 1, 1983·Cellular and Molecular Neurobiology·D GrossJ A Connor
Oct 17, 1980·Science·K IwasaR C Gibbons
Jan 1, 1997·Spatial Vision·M Jüttner, H Strasburger
Feb 18, 1958·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B C ABBOTTJ V HOWARTH
Sep 11, 1964·Science·A L HODGKIN
Aug 1, 1964·The American Journal of Cardiology·R T VANDAMJ H STUCKEY
Nov 25, 2004·Progress in Biophysics and Molecular Biology·John R Clay
Jul 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Thomas Heimburg, Andrew D Jackson
Oct 15, 1945·The Journal of Physiology·A L Hodgkin, A F Huxley
Feb 20, 2007·Biophysical Journal·G H KimB M Salzberg
Jun 2, 2009·Progress in Neurobiology·Søren S L AndersenThomas Heimburg
May 20, 1939·The Journal of General Physiology·K S Cole, H J Curtis
Apr 14, 2010·Biophysical Chemistry·T Heimburg
Apr 30, 2011·Physiological Reviews·Dominique DebanneGisèle Alcaraz
May 27, 2011·The European Physical Journal. E, Soft Matter·A-F BitbolJ-B Fournier
Feb 9, 2012·The Journal of Physiology·James HowellsDavid Burke
Aug 21, 2013·Medical Hypotheses·Helmut BarzUlrich Barz
Dec 18, 2013·Biomechanics and Modeling in Mechanobiology·Antoine JérusalemJosé M Peña
May 23, 2014·Biomechanics and Modeling in Mechanobiology·Jüri EngelbrechtTanel Peets
Aug 27, 2014·Physical Biology·Jerel K Mueller, William J Tyler
Mar 31, 2015·Nature Communications·Ahmed El Hady, Benjamin B Machta
Jul 28, 2016·Biophysical Chemistry·A Gonzalez-PerezT Heimburg
Sep 13, 2017·Soft Matter·M I Pérez-Camacho, J C Ruiz-Suárez
Feb 6, 2018·Biophysical Journal·Christian FillaferMatthias F Schneider

❮ Previous
Next ❯

Citations

Oct 11, 2020·Journal of Biological Physics·Michel Peyrard
Jul 1, 2021·Journal of the American Chemical Society·Yuecheng ZhouBianxiao Cui

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Medical Engineering & Physics
R N Miftakhov, D L Wingate
International Journal for Numerical Methods in Biomedical Engineering
F NobileR Ruiz-Baier
Proceedings of the Staff Meetings
R K WINKELMANN, R W SCHMIT
© 2022 Meta ULC. All rights reserved