Electromembrane extraction as a rapid and selective miniaturized sample preparation technique for biological fluids

Bioanalysis
Astrid GjelstadKnut Fredrik Seip

Abstract

This special report discusses the sample preparation method electromembrane extraction, which was introduced in 2006 as a rapid and selective miniaturized extraction method. The extraction principle is based on isolation of charged analytes extracted from an aqueous sample, across a thin film of organic solvent, and into an aqueous receiver solution. The extraction is promoted by application of an electrical field, causing electrokinetic migration of the charged analytes. The method has shown to perform excellent clean-up and selectivity from complicated aqueous matrices like biological fluids. Technical aspects of electromembrane extraction, important extraction parameters as well as a handful of examples of applications from different biological samples and bioanalytical areas are discussed in the paper.

References

Feb 1, 2006·Journal of Chromatography. a·Stig Pedersen-Bjergaard, Knut Einar Rasmussen
May 25, 2007·Journal of Chromatography. a·Astrid GjelstadStig Pedersen-Bjergaard
Sep 14, 2007·Journal of Chromatography. a·Astrid GjelstadStig Pedersen-Bjergaard
Sep 25, 2007·Journal of Chromatography. a·Stig Pedersen-Bjergaard, Knut Einar Rasmussen
May 16, 2008·Journal of Chromatography. a·Marte BalchenStig Pedersen-Bjergaard
Sep 17, 2008·Analytical and Bioanalytical Chemistry·Astrid GjelstadStig Pedersen-Bjergaard
Jul 2, 2010·Journal of Chromatography. a·Lars Erik Eng EibakStig Pedersen-Bjergaard
Dec 15, 2010·Analytical Chemistry·Nickolaj Jacob PetersenStig Pedersen-Bjergaard
Jan 8, 2011·Journal of Pharmaceutical and Biomedical Analysis·Mahboube EskandariShahram Seidi
Sep 9, 2011·Journal of Chromatography. a·Ragnhild Elén Gjulem JamtStig Pedersen-Bjergaard
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Jun 19, 2012·Journal of Chromatography. a·Noelia Cabaleiro DomínguezStig Pedersen-Bjergaard
Sep 21, 2012·Analytical Chemistry·Lars Erik Eng EibakAstrid Gjelstad
Dec 21, 2012·Electrophoresis·Knut Fredrik SeipStig Pedersen-Bjergaard
Sep 27, 2013·Analytical and Bioanalytical Chemistry·Lars Erik Eng EibakAstrid Gjelstad
Oct 19, 2013·Analytical and Bioanalytical Chemistry·Knut Fredrik SeipStig Pedersen-Bjergaard
May 9, 2014·Electrophoresis·Astrid Gjelstad, Stig Pedersen-Bjergaard
Mar 10, 2015·Bioanalysis·Knut Fredrik SeipStig Pedersen-Bjergaard

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Methods Mentioned

BETA
electrophoresis
chip

Software Mentioned

PaEME

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