Electromotive administration of oxybutynin into the human bladder wall

The Journal of Urology
Savino M Di StasiF Micali

Abstract

To compare concentrations of oxybutynin in the human bladder wall after either passive delivery (PD) or electromotive administration (EMDA). Tissue sections of human bladder were inserted into a diffusion cell with urothelium exposed to the donor compartment containing oxybutynin (4.5 mg. in 100 ml. NaCl 0.45%) and an anode. Twelve paired experiments, "current 5 mA/no current", were conducted over 15 minutes. Oxybutynin tissue contents were measured and tissue viability, morphology and oxybutynin stability were assessed. Mean oxybutynin tissue concentrations were 3.84 micrograms./gm. in samples exposed to EMDA and 0.87 microgram./gm. in samples exposed to PD (p = 0.0006). The mean coefficients of variation were 57.85% in EMDA experiments and 89.78% in PD experiments. Tissues were viable and undamaged histologically and no oxybutynin structural modification was observed. EMDA enhances oxybutynin administration into viable bladder wall and reduces the variability in drug delivery rate.

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Citations

Aug 7, 1998·International Urogynecology Journal and Pelvic Floor Dysfunction·H A Winkler, P K Sand
Sep 15, 2012·International Urogynecology Journal·Kelly Jirschele, Peter K Sand
Mar 29, 2008·Pharmaceutical Research·Zancong ShenJessie L-S Au
Nov 26, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·R MassoudC Cortese
May 20, 2015·Journal of Pharmaceutical Sciences·Nicholas A WilliamsHrishi B Joshi
Jan 26, 2012·Neurourology and Urodynamics·L A BirderC H Fry
Sep 12, 2006·European Urology·Antonella GiannantoniMassimo Porena
Oct 22, 2016·Urologia·Savino M Di StasiVincenzo Pagliarulo
Nov 28, 2008·BJU International·Seth P Lerner, Jessie L-S Au

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