PMID: 9449586Jan 1, 1997Paper

Electromotive drug administration of lidocaine and dexamethasone followed by cystodistension in women with interstitial cystitis

International Urogynecology Journal and Pelvic Floor Dysfunction
Anna RosamiliaJ Gibson

Abstract

Electromotive drug administration (EMDA) involves the active transport of ionized drugs such as lidocaine by the application of an electric current. Twenty-one female subjects with interstitial cystitis were treated with EMDA of lidocaine and dexamethasone, followed by cystodistension. The procedure was convenient and well tolerated, with hospital attendance for 1 hour. Bladder anesthesia was excellent, with cystodistension from a discomfort level of 200 ml to a mean volume of 600 ml. Eighty-five percent had a good response (reduction in frequency and in pain score by 3 or more) at 2 weeks, with 63% still responding at 2 months. An excellent response (pain score of 0) was present in 25% of patients reviewed at 6 months. These results are comparable to the response following cystodistension under general anesthesia. There is a need for a randomized blinded comparison of lidocaine with and without EMDA. If proven to be of pharmacological efficacy, EMDA would have many applications in facilitating procedures previously requiring general anesthesia.

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Citations

Aug 7, 1998·International Urogynecology Journal and Pelvic Floor Dysfunction·J S Gibson
Jan 27, 2006·Der Urologe. Ausg. A·J PannekM Goepel
Aug 8, 2006·Molecular Pharmaceutics·Pradeep TyagiLeaf Huang
May 20, 1998·Obstetrical & Gynecological Survey·A Rosamilia, P L Dwyer
Feb 25, 2000·The Australian & New Zealand Journal of Obstetrics & Gynaecology·P A MoranN J Radford
Jan 2, 2013·Taiwanese Journal of Obstetrics & Gynecology·Ching-Hung HsiehHan-Sun Chiang
Dec 21, 2010·Urology·Abdol-Mohammad KajbafzadehMasoud Sotoudeh
Jun 25, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Yukio HommaUNKNOWN Interstitial cystitis guideline committee
Jan 6, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Yukio HommaHikaru Tomoe
Sep 12, 2006·European Urology·Antonella GiannantoniMassimo Porena
Sep 24, 2005·Best Practice & Research. Clinical Obstetrics & Gynaecology·Anna Rosamilia
Aug 15, 2015·International Urogynecology Journal·Carolina PazinJulio Cesar Rosa-E-Silva
Feb 9, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Monika VijLinda Cardozo
Nov 28, 2012·Nature Reviews. Urology·Jochen Neuhaus, Thilo Schwalenberg
Sep 27, 2000·Current Opinion in Urology·G Hohlbrugger, C Riedl
Aug 26, 2020·Der Urologe. Ausg. A·Thomas Bschleipfer
Aug 25, 1999·Current Opinion in Urology·G R Sant, T C Theoharides

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