PMID: 1255460Feb 1, 1976Paper

Electron beam ionization mass fragmentographic analysis of tricyclic antidepressants in human plasma

Journal of Pharmaceutical Sciences
J T BiggsW R Sherman


A method for the measurement, in human plasma, of all tertiary and secondary tricyclic antidepressants prescribed in the United States is described. The method uses electron beam ionization GLC-mass spectrometry, employing a computer-controlled multiple-ion detector. This method, mass fragmentography, is used with internal standards for each drug. Plasma levels to as low as 10 ng/ml of the following drugs can be measured: amitriptyline, nortriptyline, doxepin, desmethyldoxepin, imipramine, desipramine, and protriptyline. Deuterium-labeled amitriptyline and imipramine are used as internal standards for those two drugs; for the other drugs, deuterated amitriptyline, nortriptyline, desmethyldoxepin, or desipramine is used. The method can measure up to 15 samples/hr, making it practical for large-scale studies of these drugs in patients. Spectra of each drug and examples of their analysis are given.


Feb 1, 1974·Journal of Pharmaceutical Sciences·H B Hucker, S C Stauffer
Dec 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·R A Braithwaite, B Widdop
Nov 15, 1968·Annals of the New York Academy of Sciences·T P MichaelsV J Greely
Jul 15, 1970·Life Sciences. Pt. 1: Physiology and Pharmacology·S R HarrisA A Manian
Feb 1, 1967·The British Journal of Psychiatry : the Journal of Mental Science·J P MoodyA Todrick

❮ Previous
Next ❯


Oct 1, 1978·Journal of Clinical Pharmacology·V E ZieglerS H Rosen
Jun 21, 1979·Psychopharmacology·D S RobinsonK R Lamborn
Jan 1, 1978·Life Sciences·D J BrunswickJ Mendels
Jan 1, 1979·Progress in Neuro-psychopharmacology·F Sjöqvist
Jul 1, 1977·Journal of Chromatography·J N ConnorH M Solomon
Jun 14, 2002·Journal of Pharmaceutical and Biomedical Analysis·Heinz-Werner HagedornRüdiger Schulz
Sep 14, 2001·Journal of Veterinary Pharmacology and Therapeutics·H W HagedornR Schulz
Nov 18, 1998·Fundamental & Clinical Pharmacology·H Liedholm, A Lidén
Nov 1, 1976·The Journal of Pharmacy and Pharmacology·V E ZieglerJ T Biggs
Mar 1, 1982·Journal of Toxicology. Clinical Toxicology·M V Rudorfer
Apr 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·R Virtanen
Aug 1, 1977·The British Journal of Psychiatry : the Journal of Mental Science·V E ZieglerJ T Biggs
Oct 1, 1980·Acta Pharmacologica Et Toxicologica·R VirtanenV Mattila
Jan 1, 1986·The British Journal of Psychiatry : the Journal of Mental Science·J H KocsisD Brunswick
Apr 30, 1982·Journal of Chromatography·J C CraigT L Nguyen
May 10, 1985·Journal of Chromatography·T R Norman, K P Maguire
Sep 23, 2020·The Journal of Physical Chemistry Letters·Cornelius L PieterseLuke Hanley

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.