PMID: 1255460Feb 1, 1976Paper

Electron beam ionization mass fragmentographic analysis of tricyclic antidepressants in human plasma

Journal of Pharmaceutical Sciences
J T BiggsW R Sherman

Abstract

A method for the measurement, in human plasma, of all tertiary and secondary tricyclic antidepressants prescribed in the United States is described. The method uses electron beam ionization GLC-mass spectrometry, employing a computer-controlled multiple-ion detector. This method, mass fragmentography, is used with internal standards for each drug. Plasma levels to as low as 10 ng/ml of the following drugs can be measured: amitriptyline, nortriptyline, doxepin, desmethyldoxepin, imipramine, desipramine, and protriptyline. Deuterium-labeled amitriptyline and imipramine are used as internal standards for those two drugs; for the other drugs, deuterated amitriptyline, nortriptyline, desmethyldoxepin, or desipramine is used. The method can measure up to 15 samples/hr, making it practical for large-scale studies of these drugs in patients. Spectra of each drug and examples of their analysis are given.

References

Feb 1, 1974·Journal of Pharmaceutical Sciences·H B Hucker, S C Stauffer
Dec 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·R A Braithwaite, B Widdop
Nov 15, 1968·Annals of the New York Academy of Sciences·T P MichaelsV J Greely
Jul 15, 1970·Life Sciences. Pt. 1: Physiology and Pharmacology·S R HarrisA A Manian
Feb 1, 1967·The British Journal of Psychiatry : the Journal of Mental Science·J P MoodyA Todrick

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Citations

Oct 1, 1978·Journal of Clinical Pharmacology·V E ZieglerS H Rosen
Jun 21, 1979·Psychopharmacology·D S RobinsonK R Lamborn
Jan 1, 1978·Life Sciences·D J BrunswickJ Mendels
Jan 1, 1979·Progress in Neuro-psychopharmacology·F Sjöqvist
Jul 1, 1977·Journal of Chromatography·J N ConnorH M Solomon
Jun 14, 2002·Journal of Pharmaceutical and Biomedical Analysis·Heinz-Werner HagedornRüdiger Schulz
Sep 14, 2001·Journal of Veterinary Pharmacology and Therapeutics·H W HagedornR Schulz
Nov 18, 1998·Fundamental & Clinical Pharmacology·H Liedholm, A Lidén
Nov 1, 1976·The Journal of Pharmacy and Pharmacology·V E ZieglerJ T Biggs
Mar 1, 1982·Journal of Toxicology. Clinical Toxicology·M V Rudorfer
Apr 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·R Virtanen
Aug 1, 1977·The British Journal of Psychiatry : the Journal of Mental Science·V E ZieglerJ T Biggs
Oct 1, 1980·Acta Pharmacologica Et Toxicologica·R VirtanenV Mattila
Jan 1, 1986·The British Journal of Psychiatry : the Journal of Mental Science·J H KocsisD Brunswick
Apr 30, 1982·Journal of Chromatography·J C CraigT L Nguyen
May 10, 1985·Journal of Chromatography·T R Norman, K P Maguire
Sep 23, 2020·The Journal of Physical Chemistry Letters·Cornelius L PieterseLuke Hanley

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